| 摘要: |
| 骨转换包括骨吸收和骨形成2个过程，可使用骨转换标志物（BTM）进行评价。绝经期女性雌激素水平下降，骨重建单位数量增加，骨吸收大于骨形成，BTM水平发生改变，引起骨量减少和骨密度降低，甚至发生骨质疏松症。BTM改变可能有助于骨质疏松症诊断，评估骨质疏松症患者对促进合成和抑制吸收治疗的反应性和依从性。本文对BTM在绝经期女性骨质疏松过程中的变化、骨质疏松症诊断、骨折风险预测和药物治疗反应监测等方面的研究进展进行综述。 |
| 关键词: 骨转换标志物 骨重建 绝经后骨质疏松 骨密度 |
| DOI：10.16781/j.CN31-2187/R.20220008 |
| 投稿时间：2022-01-05修订日期：2022-02-07 |
| 基金项目: |
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| Clinical application of bone turnover markers in postmenopausal osteoporosis |
| CHENG Ya-jun,CHEN Shao-feng,LI Ming,ZHOU Xiao-yi,WEI Xian-zhao* |
(Department of Orthopaedics, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Bone turnover involves 2 processes:bone resorption and bone formation, and it can be evaluated by bone turnover markers (BTM). In menopausal women, estrogen level decreases, the number of bone remodeling units increases, bone resorption is greater than bone formation, and the level of BTM changes, resulting in bone mass and bone density decrease, and even osteoporosis. Changes in BTM may contribute to the diagnosis of osteoporosis and the evaluation of responses and adherence to treatments promoting synthesis and inhibiting absorption. This article reviews the research progresses of BTM in the process of osteoporosis in menopausal women, the diagnosis of osteoporosis, the prediction of fracture risk and the response to drug treatments. |
| Key words: bone turnover markers bone remodeling postmenopausal osteoporosis bone mineral density |
