| 摘要: |
| 基孔肯雅热（CHIKF）是由基孔肯雅病毒（CHIKV）引起的以发热、皮疹和慢性关节痛为主要症状的急性传染病。CHIKF每年在全球100多个国家和地区发病约100万例，已成为重要的全球性公共卫生问题之一。疫苗接种是预防传染病最重要、最有效和最经济的手段，但是由于基础研究和临床试验的资金投入不足以及病毒持续发生适应性突变等原因，导致针对CHIKV的疫苗研发进程总体较为缓慢，迄今还没有CHIKV疫苗被批准用于临床，但已有多种候选疫苗正在进行临床试验。本综述对近年来CHIKV疫苗研究取得的进展进行了概述。 |
| 关键词: 基孔肯雅病毒 基孔肯雅热 病毒疫苗 病毒样颗粒 |
| DOI：10.16781/j.CN31-2187/R.20220074 |
| 投稿时间：2022-01-18修订日期：2022-07-01 |
| 基金项目:国家重点研发计划（2016YFC1200401）. |
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| Vaccine of Chikungunya virus: an update |
| PAN Zhen-dong,ZHAO Ping* |
(Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University(Second Military Medical University) Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Chikungunya fever (CHIKF) is an acute infectious disease caused by Chikungunya virus (CHIKV) and characterized by fever, rash and chronic joint pain. CHIKF has become one of the important global public health issues, with about 1 million cases in more than 100 countries and regions around the world each year. Vaccination is the most important, effective and economical means to prevent infectious diseases. However, due to insufficient funding for basic researches and clinical trials, as well as the continuous adaptive mutations of the virus, the development process of vaccine against CHIKV is generally slow. No licensed vaccine is yet available to prevent CHIKF, but there have been several vaccine candidates undergoing clinical trials. This review briefly summarizes the research progress on CHIKV vaccines in recent years. |
| Key words: Chikungunya virus Chikungunya fever viral vaccine virus-like particle |
