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大覆盖面积充液式抗荷措施对小型猪高过载暴露的生理防护效果
常巍△,彭智勇△,刘书林,李川涛,姚永杰*
0
(海军军医大学(第二军医大学)海军特色医学中心航空医学研究室, 上海 200433
共同第一作者
*通信作者)
摘要:
目的 探讨大覆盖面积(腋窝以下全覆盖)充液式抗荷措施对高过载暴露下小型猪的生理防护效果,验证该措施的有效性,为大覆盖面积充液式抗荷服的研究提供基础实验数据。方法 将小型猪随机分为两组:对照组(无抗荷措施,n=10)和防护组(采用大覆盖面积充液式抗荷措施,n=9)。利用载人离心机模拟+Gz暴露(基线1.4 G,增长率1 G/s,峰值8 G,峰值持续时间60 s),观察高过载暴露下小型猪的眼水平动脉血压(EABP)和+Gz耐力的变化。结果 防护组小型猪的+Gz耐力高于对照组,差异有统计学意义[28.22(19.99,251.22)G·s vs 7.58(3.65,19.57)G·s,P<0.01]。防护组小型猪+Gz峰值暴露期间EABP与暴露前相比下降幅度小于对照组,差异有统计学意义[(109.03±3.45)% vs (176.92±11.84)%,P<0.01];对照组小型猪EABP平均脉压差低于+Gz暴露前[(8.06±2.79)mmHg vs(36.96±9.80)mmHg,P<0.01;1 mmHg=0.133 kPa],防护组小型猪EABP平均脉压差与+Gz暴露前相比差异无统计学意义[(48.66±8.74)mmHg vs (45.75±8.82)mmHg,P>0.05]。结论 大覆盖面积充液式抗荷措施可明显减轻+Gz引起的EABP降低,维持脉压差平稳,提高小型猪的+Gz耐力。
关键词:  加速度耐力  大覆盖面积  充液式抗荷  加速度防护  离心机  血压
DOI:10.16781/j.CN31-2187/R.20220075
投稿时间:2022-01-18修订日期:2022-04-15
基金项目:海军军医大学(第二军医大学)舰载机飞行人才航空医学保障专项课题(2020-JY01),载人航天领域第四批预先研究项目(020101).
Physiological protective effect of extended-coverage liquid-filled anti-G measures on miniature swine during high +Gz exposure
CHANG Wei△,PENG Zhi-yong△,LIU Shu-lin,LI Chuan-tao,YAO Yong-jie*
(Department of Aviation Medicine, Naval Medical Center, Naval Medical University(Second Military Medical University), Shanghai 200433, China
Co-first authors.
* Corresponding author)
Abstract:
Objective To explore the physiological protective effect of extended-coverage (full coverage below the armpit) liquid-filled anti-G measures on miniature swine during high +Gz exposure, and validate the effectiveness of the measures, so as to provide basic experimental data for the research on extended-coverage liquid-filled anti-G suit. Methods Miniature swine were randomly divided into 2 groups:control group (without any anti-G measures, n=10) and protection group (with extended-coverage liquid-filled anti-G measures, n=9). A human centrifuge was used to simulate +Gz exposure (baseline 1.4 G, onset rate 1 G/s, peak 8 G, duration 60 s). The changes in eye-level arterial blood pressure (EABP) and +Gz tolerance of miniature swine during high +Gz exposure were observed. Results The +Gz tolerance of miniature swine in the protection group was significantly higher than that in the control group (28.22[19.99, 251.22] G·s vs 7.58[3.65, 19.57] G·s, P<0.01). The decrease of EABP of miniature swine during peak +Gz exposure in the protection group was significantly lower than that in the control group ([109.03±3.45]% vs[176.92±11.84]%, P<0.01). The mean pulse-pressure difference of EABP of miniature swine in the control group during peak +Gz exposure was lower than that before +Gz exposure ([8.06±2.79] mmHg vs[36.96±9.80] mmHg, P<0.01; 1 mmHg=0.133 kPa). There was no significant difference between the mean pulse-pressure difference of EABP of miniature swine in the protection group during peak +Gz exposure and that before +Gz exposure ([48.66±8.74] mmHg vs[45.75±8.82] mmHg, P>0.05). Conclusion The use of extended-coverage liquid-filled anti-G measures can significantly mitigate the reduction of EABP induced by +Gz, maintain smooth pulse-pressure difference, and improve +Gz tolerance of miniature swine.
Key words:  acceleration tolerance  extended-coverage  liquid-filled anti-G  acceleration protection  centrifuge  blood pressure