| 摘要: |
| 慢性胰腺炎是一种不可逆的慢性胰腺纤维化疾病。胰腺星状细胞是纤维化的关键细胞，活化的胰腺星状细胞可分泌细胞外基质促进胰腺纤维化发生、发展。胰腺腺泡细胞坏死和巨噬细胞浸润在胰腺纤维化中发挥重要作用，腺泡细胞坏死后释放多种物质激活胰腺星状细胞可能是胰腺纤维化的启动因素，而巨噬细胞的极化及表型转换可影响胰腺组织的再生修复过程。胰腺星状细胞、腺泡细胞和巨噬细胞之间存在交互作用，共同调控胰腺纤维化进程。本文主要讨论以上3种细胞在慢性胰腺炎胰腺纤维化中作用机制的最新研究进展。 |
| 关键词: 慢性胰腺炎 胰腺纤维化 胰腺星状细胞 腺泡细胞 巨噬细胞 |
| DOI：10.16781/j.CN31-2187/R.20220096 |
| 投稿时间：2022-01-25修订日期：2022-03-03 |
| 基金项目:国家自然科学基金(82070664,81770635,81900590),上海市科技创新行动计划技术标准项目(19DZ12201900),上海市扬帆计划(19YF1446800),上海市曙光计划(20SG36),上海市晨光计划(20CG42). |
|
| Mechanism of pancreatic fibrosis in chronic pancreatitis:research progress |
| LIN Xi,WANG Dan,HU Liang-hao* |
(Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Chronic pancreatitis is an irreversible chronic pancreatic fibrosis disease. Pancreatic stellate cells are the key cells of fibrosis, and activated ones can secrete extracellular matrix to promote the development and progression. Pancreatic acinar cell necrosis and macrophage infiltration are crucial in the process of pancreatic fibrosis. After necrosis, acinar cells would release various substances to activate pancreatic stellate cells, and that may be the initiating factor of fibrosis. The polarization and phenotypic switch of macrophages would affect the regeneration and repair process of pancreatic tissue. The interactions among pancreatic stellate cells, acinar cells and macrophages can jointly regulate the process of pancreatic fibrosis. This article reviews the latest progress on the roles of the above 3 kinds of cells in pancreatic fibrosis of chronic pancreatitis. |
| Key words: chronic pancreatitis pancreatic fibrosis pancreatic stellate cells acinar cells macrophages |
