| 摘要: |
| 目的 探讨可溶性肿瘤坏死因子样凋亡弱诱导剂（sTWEAK）与2型糖尿病（T2DM）患者动脉粥样硬化斑块形成的关系。方法 选择2017年6－12月于海军军医大学（第二军医大学）第一附属医院内分泌科住院治疗的T2DM患者73例为研究对象。根据有无颈动脉和/或下肢动脉斑块将患者分为有斑块组（46例）和无斑块组（27例），比较两组患者的一般资料、血生物化学指标及血清sTWEAK水平。采用Spearman相关性分析评估血清sTWEAK水平与各临床参数的相关性。采用logistic回归分析评估动脉粥样硬化斑块形成的影响因素。结果 有斑块组患者的年龄和血清sTWEAK水平均高于无斑块组[（55.87±10.65）岁vs（44.04±11.96）岁，P＝0.001；79.53（26.87，113.03）pg/mL vs 47.70（18.62，78.15）pg/mL，P＝0.018]。Spearman相关性分析显示，血清sTWEAK水平与患者年龄（r＝0.247，P＝0.035）、斑块数量（r＝0.270，P＝0.021）呈正相关。logistic回归分析显示，年龄是T2DM患者动脉粥样硬化斑块形成的独立危险因素（OR＝1.091，95% CI 1.036~1.148，P＝0.001），而血清sTWEAK水平并非独立危险因素（OR＝1.012，95% CI 0.999~1.025，P＝0.063）。结论 伴有动脉粥样硬化斑块的T2DM患者有更高的血清sTWEAK水平，其血清sTWEAK水平的升高可能与年龄相关。 |
| 关键词: 可溶性肿瘤坏死因子样凋亡弱诱导剂 2型糖尿病 动脉粥样硬化斑块 危险因素 |
| DOI：10.16781/j.CN31-2187/R.20220212 |
| 投稿时间：2022-03-12 |
| 基金项目:上海市2020年度科技创新行动计划医学创新研究专项（20Y11905200） |
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| Relationship between serum sTWEAK levels and atherosclerotic plaque in patients with type 2 diabetes mellitus |
| HAO Wei1,WAN Ren-hui2,ZHENG Long-yi1,LU Jin1* |
(1. Department of Endocrinology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Endocrinology, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the relationship between soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and atherosclerotic plaque formation in patients with type 2 diabetes mellitus (T2DM).Methods A total of 73 T2DM patients hospitalized in Department of Endocrinology of The First Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jun. to Dec. 2017 were enrolled, and were divided into plaque group (46 cases) and non-plaque group (27 cases). General data, blood biochemical indexes and serum sTWEAK levels of the 2 groups were compared. The correlation between sTWEAK and each clinical index was evaluated using Spearman correlation analysis. Influencing factors of atherosclerotic plaque formation were evaluated using logistic regression analysis.Results Compared with non-plaque group, the age and serum sTWEAK level were significantly higher in the plaque group ([55.87±10.65] years old vs [44.04±11.96] years old, P＝0.001; 79.53 [26.87, 113.03] pg/mL vs 47.70 [18.62, 78.15] pg/mL, P＝0.018). Spearman correlation analysis showed that serum sTWEAK level was positively correlated with age (r＝0.247, P＝0.035) and number of plaques (r＝0.270, P＝0.021). Logistic regression analysis showed that age was an independent risk factor of atherosclerotic plaque formation in T2DM patients (odds ratio [OR]＝1.091, 95% confidence interval [CI] 1.036-1.148, P＝0.001), while serum sTWEAK was not an independent risk factor (OR＝1.012, 95% CI 0.999-1.025, P＝0.063).Conclusion T2DM patients with atherosclerotic plaques have higher serum sTWEAK levels, and the increase of serum sTWEAK levels may be related to age. |
| Key words: soluble tumor necrosis factor-like weak inducer of apoptosis type 2 diabetes mellitus atherosclerotic plaque risk factors |
