| 摘要: |
| 支气管哮喘（简称哮喘）缺乏特别有效的治疗手段。间充质干细胞（MSC）因具有抑制炎症、改善气道重塑的作用及可经呼吸道给药等优势，在哮喘治疗领域被广泛研究。虽然近年来对MSC治疗哮喘的应用性探索不断涌现，但其治疗哮喘的临床试验结果并不理想。不同类型的干细胞、不同哮喘患者的病理生理特征的差异给MSC的临床应用带来了严峻的挑战。本文就目前MSC治疗哮喘的作用机制研究及临床应用挑战进行回顾分析，以更好地了解MSC治疗哮喘的潜力及临床应用的可行性。 |
| 关键词: 哮喘 间充质干细胞 免疫调节 临床应用 |
| DOI：10.16781/j.CN31-2187/R.20220260 |
| 投稿时间：2022-03-30修订日期：2022-05-31 |
| 基金项目:国家自然科学基金面上项目（81873405），上海市青年科技英才扬帆计划（21YF1459000）. |
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| Mesenchymal stem cells in the treatment of bronchial asthma: challenges and strategies |
| QU Yu-lan1,GE Xia-hui2,BAI Chong1* |
(1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Respiratory Medicine, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
*Corresponding author) |
| Abstract: |
| Bronchial asthma (abbreviated as asthma) lacks a particularly effective treatment. Mesenchymal stem cells (MSCs) have been widely studied in the field of asthma treatment for their roles in inhibiting inflammation and improving airway remodeling, as well as their advantages in respiratory tract administration. In recent years, although the exploration of MSCs on the treatment of asthma has been surging, the results of the clinical trials are not satisfactory. The differences in types of stem cells and pathophysiological characteristics of asthma patients have posed serious challenges to the clinical application of MSCs. This article reviews the current studies on the mechanism and clinical application challenges of MSCs in the treatment of asthma, so as to better understand the therapeutic potential and clinical feasibility of MSCs. |
| Key words: asthma mesenchymal stem cells immunomodulation clinical application |
