| 摘要: |
| 目的 分析血清7种miRNA（7miRNAs，包括miRNA-122、miRNA-192、miRNA-21、miRNA-223、miRNA-26a、miRNA-27a和miRNA-801）单独或联合甲胎蛋白（AFP）检测对肝细胞癌（HCC）的诊断价值。方法 选择2021年1月至2021年6月我院收治的249例患者为研究对象，其中163例为确诊的HCC患者（HCC组）、86例为非HCC患者（非HCC组）。检测两组患者血清7miRNAs和AFP水平，根据临床既定标准（7miRNAs≥－0.5 和/或AFP≥20 ng/mL为阳性）计算2个指标单独和联合检测诊断HCC的灵敏度、特异度、阳性预测值和阴性预测值。运用ROC曲线分析2个指标单独及联合检测对HCC的诊断价值。结果 在249例患者中，HCC组患者的7miRNAs和AFP水平均高于非HCC组患者，差异均有统计学意义（P均＜0.01）。血清7miRNAs、AFP和两者联合检测诊断HCC的灵敏度分别为75.46%、57.06%和87.12%，特异度分别为74.42%、94.19%和69.77%，阳性预测值分别为84.83%、94.90%和84.52%，阴性预测值分别为61.54%、53.64%和74.07%，AUC分别为0.787、0.819和0.864。结论 血清7miRNAs和AFP联合检测对HCC的诊断效能优于AFP单独检测，有更高的诊断价值。 |
| 关键词: 肝细胞癌 甲胎蛋白 7种微RNA 诊断价值 |
| DOI：10.16781/j.CN31-2187/R.20220648 |
| 投稿时间：2022-08-03修订日期：2022-11-14 |
| 基金项目:国家科技重大专项(2012ZX10002016003003). |
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| Values of serum 7 microRNAs alone or in combination with α-fetoprotein in diagnosing hepatocellular carcinoma |
| ZHANG Jing-lei,SHEN Qiang,WANG Neng,SHENG Yue-hong,QIAN Guo-jun,LU Zheng-hua* |
(Department of Ultrasonic Intervention, The Third Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Objective To analyze the roles of serum 7 microRNAs (7miRNAs, including miRNA-122, miRNA-192, miRNA-21, miRNA-223, miRNA-26a, miRNA-27a, and miRNA-801) alone or in combination with α-fetoprotein (AFP) in diagnosing hepatocellular carcinoma (HCC). Methods A total of 249 patients who were admitted to our hospital from Jan. 2021 to Jun. 2021 were enrolled, including 163 patients with confirmed HCC (HCC group) and 86 patients without HCC (non-HCC group). The serum levels of 7miRNAs and AFP were measured in the 2 groups, and based on the established clinical criteria (7miRNAs≥－0.5 and/or AFP≥20 ng/mL were positive), the sensitivity, specificity, positive predictive value and negative predictive value of the 2 indicators were calculated for the diagnosis of HCC alone and in combination. The receiver operating characteristic curve was used to analyze the diagnostic value of the 2 indicators used alone or in combination for HCC. Results Among 249 patients, the levels of 7miRNAs and AFP in the HCC group were significantly higher than those in the non-HCC group (both P＜0.01). The sensitivities of serum 7miRNAs, AFP and their combination were 75.46%, 57.06% and 87.12% for the diagnosis of HCC, respectively; the specificities were 74.42%, 94.19% and 69.77%, respectively; the positive predictive values were 84.83%, 94.90% and 84.52%, respectively; the negative predictive values were 61.54%, 53.64% and 74.07%, respectively; and the area under curve values were 0.787, 0.819 and 0.864, respectively. Conclusion The combined detection of serum 7miRNAs and AFP has higher diagnostic value than that of AFP used alone for HCC. |
| Key words: hepatocellular carcinoma α-fetoprotein 7 microRNAs diagnostic value |
