| 摘要: |
| 生物钟是将个体生理节律与外部时间联系起来的重要机制，能预测并响应时间变化，决定睡眠-觉醒周期，参与调节摄食、体内激素平衡等多种生理行为的昼夜节律。哺乳动物体内中枢生物钟能够调节肠道、肝脏、胰腺等外周生物钟，维持各器官稳态并同步运行，并能通过调控进食和睡眠等诱导肠道微生物结构、数量和定植行为的昼夜改变。肠道微生物是肠道微生态的核心部分，能够对包括大脑在内的多器官、多系统发挥调节作用，并被证明是宿主生物钟分子节律性表达和多种昼夜节律活动的驱动因素。研究已经部分揭示了哺乳动物肠道微生态和生物钟之间的关联，以及它们对疾病的影响，但仍需进一步探究它们在不同疾病背景下相互作用的具体机制。本文综述了目前有关哺乳动物生物钟与肠道微生态间的双向调控关系及可能机制的研究进展，以期为疾病治疗提供新的干预措施和治疗靶点。 |
| 关键词: 生物钟 肠道微生态 动态变化 双向调节 |
| DOI：10.16781/j.CN31-2187/R.20220819 |
| 投稿时间：2022-10-23修订日期：2023-02-23 |
| 基金项目:军队后勤科研计划课题(ALB19J003). |
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| Bidirectional regulation between circadian clock and intestinal microecology |
| WANG Fan,YANG Guangrui,HUANG Wen,LI Zhaoshen* |
(Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| The circadian clock is an important mechanism that links individual rhythm with external time. It can predict and respond to time, determine sleep-wake cycle, and participate in the regulation of circadian rhythms of various physiological behavior changes, including food intake and hormone balance in the body. The central circadian clock in mammals can regulate the peripheral circadian clocks of the gut, liver, and pancreas and other organs to maintain homeostasis and synchronize the operation of each organ, which can induce circadian changes in the structure, number, and colonization behavior of gut microbes by regulating feeding and sleep. Gut microbiota are the core part of intestinal microecology, which can regulate the physiology and functions of multiple organs and systems, including the brain, and have been proved to be the driving factors of the rhythmic expression of host clock molecules and a variety of circadian rhythm activities. In the past few years, the relationship between mammalian gut microbiota and circadian clock and their impact on diseases have been partially revealed, but further research is still needed to explore the specific mechanism of their cooperation in the context of human diseases. This paper reviews the current research progress on the bidirectional regulation between mammalian circadian clock and gut microbiota and the specific molecular mechanisms involved, hoping to provide new interventions and therapeutic targets for the treatment of diseases. |
| Key words: circadian clock intestinal microecology dynamic change bidirectional regulation |
