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外泌体在甲状腺癌诊治中的研究进展
童修文,马冠君,徐昕昀*
0
(海军军医大学(第二军医大学)第二附属医院甲乳疝外科, 上海 200003
*通信作者)
摘要:
甲状腺癌是世界上发病率增长最快的癌症之一,寻找新型高特异性、高灵敏度、无创的早期诊断和术后检测标志物成为研究热点。外泌体是细胞间信息物质交流的重要载体,由于其高稳定性、低细胞毒性、低免疫原性和高膜通透性等特征,具有成为无创、新型疾病诊断和治疗手段的潜能。近年来,外泌体在甲状腺癌非侵入性诊断、检测、给药、治疗和预后评估等领域取得了实质性突破。本文综述了甲状腺癌来源的外泌体在肿瘤发生、发展及诊断和治疗中的研究进展。
关键词:  外泌体  细胞外囊泡  微RNA  甲状腺癌  生物标志物  诊断
DOI:10.16781/j.CN31-2187/R.20220864
投稿时间:2022-11-08修订日期:2023-04-25
基金项目:
Exosome in diagnosis and treatment of thyroid carcinoma: research progress
TONG Xiuwen,MA Guanjun,XU Xinyun*
(Department of Thyroid, Breast and Hernia, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author)
Abstract:
Thyroid carcinoma (TC) is one of the fastest-growing cancers in the world. Finding new biomarkers with high specificity, high sensitivity and non-invasive characteristic for early diagnosis and postoperative detection has become a research focus. Exosome, an important carrier of intercellular communication with high stability, low cytotoxicity, low immunogenicity, and high membrane permeability, has the potential to become a non-invasive and new means of disease diagnosis and treatment. In recent years, there have been substantial breakthroughs for exosomes in non-invasive diagnosis, detection, administration, treatment, and prognostic evaluation of thyroid cancer. This article reviews the research progress of TC-derived exosomes in tumor development and progression, diagnosis, and therapy.
Key words:  exosome  extracellular vesicles  microRNA  thyroid carcinoma  biomarkers  diagnosis