| 摘要: |
| 卵巢癌、子宫内膜癌、宫颈癌是妇科三大恶性肿瘤，严重危害着女性的生命健康。肿瘤的发生与发展是一个复杂过程，与肿瘤微环境密切相关。肿瘤相关成纤维细胞（CAF）是肿瘤微环境的重要组成部分，具有分泌多种细胞因子及合成细胞基质蛋白的能力。成纤维细胞激活蛋白（FAP）是CAF最具潜力的分子标志物之一，能够促进肿瘤细胞增殖、迁移、侵袭，重塑细胞外基质，诱导肿瘤新生血管生成，是参与肿瘤发生、发展必不可少的因素。FAP作为肿瘤诊断示踪剂及作为靶向药物的研究也取得了一定进展，为妇科恶性肿瘤的诊治研究提供了新方向。 |
| 关键词: 成纤维细胞激活蛋白 妇科恶性肿瘤 卵巢癌 宫颈癌 子宫内膜癌 |
| DOI：10.16781/j.CN31-2187/R.20230031 |
| 投稿时间：2023-02-05修订日期：2023-07-10 |
| 基金项目:海军军医大学（第二军医大学）第一附属医院“234学科攀峰计划”（2019YXK014）. |
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| Role of fibroblast activation protein in gynaecological malignancies: research progress |
| LU Nan,LIU Chenwu,CHEN Jun,XU Mingjuan* |
(Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Three major gynecological malignancies (ovarian cancer, endometrial cancer, and cervical cancer) severely affect women’s life and health. The development and progression of tumors are complex and closely related to the tumor microenvironment. Cancer-associated fibroblast (CAF) is an important part of the tumor microenvironment, having the ability to secrete a variety of cytokines and synthesize cell-matrix proteins. Fibroblast activation protein (FAP) is one of the most potential molecular markers of CAF, can promote the proliferation, migration, and invasion of tumor cells, remodel the extracellular matrix, and induce tumor neovascularization. It is an indispensable factor in tumorigenesis. The research of FAP (as a tumor diagnostic tracer and a targeted drug) has made some progress, which provides a new direction for the diagnosis and treatment of gynecological malignancies. |
| Key words: fibroblast activation protein gynecological malignancy ovarian carcinoma cervical carcinoma uterine endometrial carcinoma |
