| 摘要: |
| 肠道微生物群是人体内存在的重要生物群落，相关研究日益深入，但麻醉药物对肠道微生物群影响的研究还非常有限。本文回顾分析了吸入麻醉药、静脉麻醉药、阿片类药物与肠道微生物群相互作用的研究文献，结果显示麻醉药物能改变肠道微生物群的组成并对其功能产生影响，这些变化与术后认知功能障碍、脓毒症等疾病存在相关性。当前的研究缺乏大样本及全面的数据分析，未来需要完善研究方法，并逐步将研究对象由动物转移到人类，以揭示相关的作用机制，为麻醉药物的使用提供指导，并更好地为患者手术治疗及术后康复提供服务。 |
| 关键词: 肠道微生物群 麻醉药物 术后认知功能障碍 脓毒症 |
| DOI：10.16781/j.CN31-2187/R.20230318 |
| 投稿时间：2023-06-09修订日期：2023-10-19 |
| 基金项目:国家自然科学基金(82272205). |
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| Impact of anesthetic drugs on intestinal microflora: research progress |
| LIU Jiahao1,WANG Ying1,MENG Yuhang2,WANG Ting1,BIAN Jinjun1* |
(1. Department of Anesthesiology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Northern Medical Branch of Chinese PLA General Hospital, Beijing 100094, China
*Corresponding author) |
| Abstract: |
| Intestinal microflora is an important biological community in human body. Extensive research has been done in this filed, but investigation on the influence of anesthetic drugs on intestinal microflora remains limited. We analyzed the research literature on the interaction between intestinal microflora and inhaled anesthetics, intravenous anesthetics, and opioid medications. The results showed that anesthetic drugs could change the composition of the intestinal microflora and influence its function. And these changes were related to postoperative cognitive dysfunction, sepsis, and other diseases. However, current research lacks large-scale studies and comprehensive data analysis. Future efforts should focus on refining research methodologies and transitioning from animal models to human studies to elucidate the underlying mechanisms, provide guidance for the use of anesthetic drugs, and enhance surgical treatment and postoperative recovery of patients. |
| Key words: intestinal microflora anesthetic drugs postoperative cognitive dysfunction sepsis |
