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| 生长分化因子15在衰老、代谢和炎症相关疾病中的作用 |
| 杜涵1,赫明达1,庞妍2,刘清桂1,高俊灵1,王敏君1,2* |
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(1. 海军军医大学(第二军医大学)基础医学院细胞生物学教研室, 上海 200433;
2. 上海理工大学公利医疗技术学院精准医疗与再生医学系, 上海 200135
*通信作者) |
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| 摘要: |
| 生长分化因子15（GDF15）是TGF-β超家族的成员，在人体多种组织中表达。正常生理条件下GDF15在除胎盘和前列腺组织以外的其他组织中表达量均较低，随着衰老的发生、运动或压力的刺激，GDF15蛋白的表达水平明显增高。GDF15与其受体胶质细胞源性神经营养因子家族受体α样（GFRAL）蛋白结合后，可促进细胞内脂肪酸β氧化和脂质分解，从而缓解脂肪肝等的发展，同时也能降低机体的食物摄入量从而抑制肥胖。GDF15还可作为炎症因子调控衰老和纤维化相关疾病的发生。本文主要概述GDF15在衰老、代谢和炎症相关疾病中的调控作用，为开发以GDF15为靶点的疾病治疗策略提供思路。 |
| 关键词: 生长分化因子15 衰老 脂肪代谢 炎症 纤维化 |
| DOI：10.16781/j.CN31-2187/R.20230524 |
| 投稿时间：2023-09-15修订日期：2024-02-27 |
| 基金项目:国家自然科学基金（32070732），上海市科学技术委员会“科技创新行动计划”启明星项目（21QA1411400）. |
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| Role of growth differentiation factor 15 in aging, metabolism and inflammation-related diseases |
| DU Han1,HE Mingda1,PANG Yan2,LIU Qinggui1,GAO Junling1,WANG Minjun1,2* |
(1. Department of Cell Biology, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Precision and Regenerative Medicine, School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200135, China
* Corresponding author) |
| Abstract: |
| Growth differentiation factor 15 (GDF15), a member of the transforming growth factor β (TGF-β) superfamily, is widely expressed in multiple tissues. Under normal physiological conditions, the expression of GDF15 is low in all tissues except for placenta and prostate. However, with aging and exercise or stress stimulation, the GDF15 level is significantly increased. GDF15 binds its reporter, glial cell line derived neurotrophic factor family receptor α-like (GFRAL), to induce the intracellular fatty acids β oxidation and lipolysis, subsequently alleviating the development of fatty liver and inhibiting obesity through decreased food intake. GDF15 is also considered as an inflammatory factor regulating aging and fibrosis related diseases. This article mainly summarizes the regulatory role of GDF15 in aging, metabolism and inflammation-related diseases, so as to provide insights for the treatment strategies targeting GDF15. |
| Key words: growth differentiation factor 15 aging lipometabolism inflammation fibrosis |
