| 摘要: |
| 脓毒症是因机体对感染的免疫反应失衡引起的一种威胁生命的多器官功能障碍综合征，其病情复杂多变，是导致ICU患者死亡的主要原因之一。肺损伤是脓毒症患者常见的器官损伤。巨噬细胞是先天性免疫和适应性免疫的重要组成部分，可通过不同的极化类型主导机体免疫状态，在脓毒症的早期常呈现促炎的M1型极化并导致免疫亢进，而在脓毒症后期又往往转化为抑炎的M2型造成免疫抑制。Janus激酶（JAK）/信号转导及转录激活蛋白（STAT）通路对炎症信号的调节具有重要作用，该通路的激活贯穿了整个脓毒症发展及巨噬细胞极化的全过程。本文分析了JAK/STAT通路通过影响巨噬细胞极化进而介导脓毒症相关肺损伤的作用机制，并总结了潜在的治疗靶点，以期为脓毒症的治疗提供新思路。 |
| 关键词: 脓毒症 急性肺损伤 巨噬细胞极化 Janus激酶 信号转导及转录激活蛋白 |
| DOI：10.16781/j.CN31-2187/R.20240103 |
| 投稿时间：2024-02-07修订日期：2024-04-22 |
| 基金项目:国家自然科学基金（82071769），上海市长宁区卫生健康委员会医学重点专科（20231005），上海市长宁区卫生健康委员会青年课题（2023QN23），海军军医大学（第二军医大学）“深蓝”人才工程启航计划. |
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| Role of JAK/STAT pathway in regulating macrophage polarization in sepsis-associated lung injury |
| WU Yuxian1,WANG Yusheng1,LIU Yaoyang2,JIANG Zeping1,LIU Yang1* |
(1. Department of Critical Care Medicine, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai 200050, China;
2. Department of Clinical Genetics, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
* Corresponding author) |
| Abstract: |
| Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an imbalanced immune response to infection. Its condition is complex and variable, and it is one of the main causes of death in intensive care unit. Lung injury is the common organ injury in sepsis patients. Macrophages are an important component of innate and adaptive immunity that can dominate immune status through different polarization types. At the early stage of sepsis, macrophages often polarize to pro-inflammatory M1-like and lead to immune hyperactivity, while convert to anti-inflammatory M2-like at the late stage, resulting in immunosuppression. Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays an important role in the regulation of inflammatory signals, and the activation of the pathway occurs throughout the entire process of sepsis development and macrophage polarization. This review analyzes how the JAK/STAT pathway mediates the development of sepsis-associated lung injury by affecting macrophage polarization, and summarizes the potential therapeutic targets, with a view to provide new ideas for the treatment of sepsis. |
| Key words: sepsis acute lung injury macrophage polarization Janus kinase signal transducer and activator of transcription |
