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| 甲状腺癌分子标志物及其在临床诊疗中的应用进展 |
| 滕伟强1,2,王秋阳2,马毅1,张才云1,郑宏良1,朱乘婧1,刘济生2* |
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(1. 海军军医大学(第二军医大学)第一附属医院耳鼻咽喉头颈外科, 上海 200433;
2. 苏州大学第一附属医院耳鼻咽喉头颈外科, 苏州 215000
*通信作者) |
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| 摘要: |
| 甲状腺癌发病与环境因素密切相关，环境变化导致的基因突变和腺体组织分子生物学改变是诱发甲状腺癌的重要因素之一。尽管甲状腺癌的相关分子机制仍未完全阐明，但随着分子生物学技术的发展，越来越多的甲状腺癌特定遗传改变和分子标志物被挖掘出来。本文就甲状腺癌的病因、特异性分子标志物、诊断及靶向治疗研究进展进行综述，为甲状腺癌的临床诊疗提供理论支持。 |
| 关键词: 甲状腺肿瘤 分子机制 分子标志物 癌基因 基因突变 基因重排 |
| DOI：10.16781/j.CN31-2187/R.20230088 |
| 投稿时间：2023-03-01修订日期：2023-10-23 |
| 基金项目:国家自然科学基金（81970868，81972537，81200734）. |
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| Thyroid carcinoma biomarkers and its application in clinical diagnosis and treatment: recent progress |
| TENG Weiqiang1,2,WANG Qiuyang2,MA Yi1,ZHANG Caiyun1,ZHENG Hongliang1,ZHU Chengjing1,LIU Jisheng2* |
(1. Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu, China
* Corresponding author) |
| Abstract: |
| Thyroid carcinoma is closely related to environmental factors. Gene mutations and molecular biological changes of gland tissue caused by environmental changes are important factors inducing thyroid carcinoma. Although the molecular mechanism of thyroid carcinoma has not been fully elucidated, increasingly specific genetic changes and molecular markers for thyroid carcinoma have been discovered with the development of molecular biology techniques. This article reviews the recent progresses on the etiology, specific molecular markers, diagnosis and targeted therapies of thyroid carcinoma, so as to provide theoretical support for the clinical diagnosis and treatment of thyroid carcinoma. |
| Key words: thyroid neoplasms molecular mechanism molecular markers oncogene gene mutation gene rearrangement |
