| 摘要: |
| 急性胰腺炎是经内镜逆行胰胆管造影（ERCP）术后最常见的不良事件，尽管使用了多种预防性措施，其仍是临床面临的一个棘手问题。近年来，钙调磷酸酶在胰腺炎发病机制中的作用受到关注，其特异性抑制剂为ERCP术后胰腺炎的预防提供了新的很有前景的方向。本文就近年来钙调磷酸酶及其抑制剂与ERCP术后胰腺炎预防相关的基础和临床研究进展作一综述，以期为后续研究提供更多思路。 |
| 关键词: 经内镜逆行胰胆管造影 急性胰腺炎 钙调磷酸酶抑制剂 发病机制 预防 |
| DOI：10.16781/j.CN31-2187/R.20230582 |
| 投稿时间：2023-10-24修订日期：2024-04-19 |
| 基金项目: |
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| Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with calcineurin inhibitors: research progress |
| LI Jiasu1,LIU Feng2*,LI Zhaoshen1 |
(1. Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China
*Corresponding author) |
| Abstract: |
| Acute pancreatitis is the most common adverse event after endoscopic retrograde cholangiopancreatography (ERCP), and it remains a challenging clinical issue despite the use of various preventive measures. In recent years, the role of calcineurin in the pathogenesis of pancreatitis has received attention, and its specific inhibitors provide a new and promising direction for preventing post-ERCP pancreatitis. This article reviews the basic and clinical progress on the relationship between calcineurin and its inhibitors and the prevention of post-ERCP pancreatitis in recent years, hoping to provide more ideas for future research. |
| Key words: endoscopic retrograde cholangiopancreatography acute pancreatitis calcineurin inhibitors pathogenesis prevention |
