| 摘要: |
| 强直性脊柱炎为难治性自身免疫性疾病，异位骨化是其最主要的病理特征之一。强直性脊柱炎异位骨化的发生机制涉及多个方面，包括骨化相关基因、骨化相关因子、骨化相关细胞、骨化信号通路和机械应力等。本文从多途径、多通路、多靶点、多因子的不同方面阐述了强直性脊柱炎异位骨化的发生机制，以期为拓展临床及基础研究、深入认识强直性脊柱炎提供参考。 |
| 关键词: 强直性脊柱炎 异位骨化 成骨信号通路 成骨细胞 |
| DOI：10.16781/j.CN31-2187/R.20240165 |
| 投稿时间：2024-03-13修订日期：2024-08-27 |
| 基金项目:北京市中医药科技发展资金重点项目（BJZYZD-2023-02），中国中医科学院科技创新工程重点协同攻关项目（CI2023C072YLL），中国中医科学院科技创新工程重大攻关项目（CI2021A01506），中央高水平中医医院临床研究和成果转化能力提升项目（HLCMHPP2023049），中国中医科学院拔尖创新博士研究生支持计划. |
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| Mechanism of heterotopic ossification in ankylosing spondylitis: research progress |
| CHEN Yuening,YU Qing,LIU Hongxiao* |
(Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
*Corresponding author) |
| Abstract: |
| Ankylosing spondylitis is a refractory autoimmune disease, and heterotopic ossification is one of the most important pathological features.The mechanism of heterotopic ossification in ankylosing spondylitis involves many aspects, including ossification-related genes, ossification-related factors, ossification-related cells, ossification signaling pathways, and mechanical stress.This article elaborates the pathogenesis of heterotopic ossification in ankylosing spondylitis from different aspects of multiple channels, pathways, targets, and factors, hoping to provide reference for expanding clinical and basic research and in-depth understanding of ankylosing spondylitis. |
| Key words: ankylosing spondylitis ectopic ossification ossification signaling pathway osteoblasts |
