| 摘要: |
| 随着分子病理与高通量测序技术的广泛应用，人们对淋巴造血组织肿瘤基因组特征的认识越来越深入。基因检测技术及其带来的新进展对推动淋巴瘤诊疗具有重要意义。本文介绍了用于淋巴瘤病理诊断与研究的新技术，包括全基因组测序、循环肿瘤DNA分析、单细胞分析和表观遗传学研究等；并以新版WHO淋巴造血组织肿瘤分类为基础，阐述了常见淋巴瘤的基因特征、预后分层与治疗的最新进展，以指导淋巴瘤的病理诊断与临床治疗。 |
| 关键词: 基因检测 淋巴瘤 辅助诊断 治疗 |
| DOI：10.16781/j.CN31-2187/R.20230551 |
| 投稿时间：2023-10-16修订日期：2024-01-18 |
| 基金项目:上海市科学技术委员会科技支撑项目（18411963000）. |
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| Genetic detection in diagnosis and treatment of lymphoma |
| JIAO Lijuan,HE Miaoxia* |
(Department of Pathology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Many genomic features of lymphohematopoietic tissue tumors have been recognized by molecular pathological testing and high-throughput sequencing technology. The gene detection technology and its progress are of great significance for the diagnosis and treatment of lymphoma. This paper introduces new technologies for the pathological diagnosis and research of lymphoma, including whole genome sequencing, circulating tumor DNA analysis, single cell analysis and epigenetic research, etc. The latest progress in the genetic characteristics, prognostic stratification and treatment prospects of common lymphoma based on the new WHO classification of lymphohematopoietic tissue tumors will help to guide the pathological diagnosis and clinical treatment of lymphoma. |
| Key words: genetic testing lymphoma auxiliary diagnosis treatment |
