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| 肝细胞癌转化治疗：从不可切除到可切除的新希望 |
| 钟承千1,2,3,林孔英1,2,曾永毅1,2* |
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(1. 福建医科大学孟超肝胆医院肝胆胰外科, 福州 350007;
2. 福建省肝胆医学中心, 福州 350007;
3. 福建医科大学附属龙岩第一医院普外三科, 龙岩 364000
*通信作者) |
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| 摘要: |
| 肝细胞癌（HCC）临床预后差，主要原因是其发病隐匿，多数患者初诊时已达中晚期，失去了手术指征。随着新型靶向药物、免疫药物及局部治疗等多维治疗方案的联合应用，HCC的客观缓解率显著提高，为HCC转化治疗奠定了基础。转化治疗是近年来HCC治疗领域的重要突破，旨在将不可切除肿瘤转化为可切除状态，已成为不可切除HCC的有效治疗手段。然而，HCC转化治疗仍面临诸多挑战，本文根据笔者临床经验及HCC转化治疗最新进展，对HCC转化治疗策略及疗效进行阐述。 |
| 关键词: 肝肿瘤 不可切除肝细胞癌 转化治疗 肝切除术 |
| DOI：10.16781/j.CN31-2187/R.20240384 |
| 投稿时间：2024-05-30修订日期：2024-09-25 |
| 基金项目:国家自然科学基金面上项目（62275050），福建省科技创新联合资金项目（2019Y9108），福建省卫生健康委员会中青年科研重大项目（2021ZQNZD013）. |
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| Conversion therapy for hepatocellular carcinoma: from unresectable to resectable |
| ZHONG Chengqian1,2,3,LIN Kongying1,2,ZENG Yongyi1,2* |
(1. Department of Hepatobiliary and Pancreatic Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350007, Fujian, China;
2. Hepatobiliary Medical Center of Fujian Province, Fuzhou 350007, Fujian, China;
3. Department of General Surgery (Ⅲ), Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian, China
*Corresponding author) |
| Abstract: |
| Hepatocellular carcinoma (HCC) still has a poor clinical prognosis, mainly due to its insidious onset, and most patients have reached an advanced stage at initial diagnosis and lost the indications for surgery. With the combined application of multidimensional therapeutic options such as novel targeted drugs, immune drugs and local therapies, the objective response rate of HCC has greatly improved, laying a foundation for conversion therapy. Conversion therapy is a major breakthrough for the treatment of HCC lately, and it aims to make unresectable tumors resectable, and has now become an effective treatment for unresectable HCC. However, conversion therapy of HCC still faces many challenges. The paper provides an in-depth description of the strategies and efficacy of conversion therapy for HCC based on the authors’ clinical experience and the latest advances in this field. |
| Key words: liver neoplasms unresectable hepatocellular carcinoma conversion therapy hepatectomy |
