| 摘要: |
| 食管癌是常见的恶性肿瘤之一，我国是食管癌的高发国家。由于食管癌预防难、发现晚，有效防控是研究的热点和临床难点。以循环肿瘤DNA（ctDNA）为代表的液态活检技术的发展为食管癌早期诊断、治疗评估及预后监控提供了一种新的思路。ctDNA检测方法具有高特异度及高灵敏度，可以应用于肿瘤的筛查及诊断，并且在判断预后、指导治疗方面也具有很高的应用价值。本文就ctDNA检测技术及其在食管癌诊疗中的研究进展进行阐述。 |
| 关键词: 食管肿瘤 循环肿瘤DNA 筛查 诊断 临床决策 预后 |
| DOI：10.16781/j.CN31-2187/R.20220217 |
| 投稿时间：2022-03-14修订日期：2022-11-14 |
| 基金项目:上海市科学技术委员会课题（15411951700）. |
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| Application of circulating tumor DNA in whole process management of patients with esophageal cancer: research progress |
| LIU Tao1,JIN Hai2* |
(1. Department of Thoracic Surgery, Peking University First Hospital, Beijing 100034, China;
2. Department of Thoracic Surgery, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Esophageal cancer is one of the common malignant tumors, and its incidence in China is high. Effective prevention and control is a focus and challenge due to difficult prevention and late diagnosis. The development of liquid biopsy technology represented by circulating tumor DNA (ctDNA) provides new insights for early diagnosis, treatment evaluation and prognosis monitoring of esophageal cancer. ctDNA detection method has high specificity and sensitivity, which can be used in tumor screening and diagnosis, and has high application value in judging prognosis and guiding treatment. This article reviews the detection technology of ctDNA and the research progress in the diagnosis and treatment of esophageal cancer. |
| Key words: esophageal neoplasms circulating tumor DNA screening diagnosis clinical decision prognosis |
