| 摘要: |
| 青少年特发性脊柱侧凸（AIS）是一种发生于10～18岁青少年的脊柱畸形，在女性青少年中尤为常见。尽管已有许多AIS相关的研究报道，但其病理机制仍不清楚。因AIS患者存在骨骼生长异常和骨密度降低的病理变化，间充质干细胞（MSC）在骨代谢异常中的作用被认为是AIS的一种可能致病机制。本文总结了MSC在AIS发病机制中的作用，并对MSC的未来临床应用提出展望。 |
| 关键词: 间充质干细胞 青少年特发性脊柱侧凸 发病机制 骨代谢 |
| DOI：10.16781/j.CN31-2187/R.20240041 |
| 投稿时间：2024-01-16修订日期：2024-05-07 |
| 基金项目:海军军医大学（第二军医大学）第一附属医院科普创新创优专项资助计划（chkpyy011）. |
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| Role of mesenchymal stem cells in pathogenesis of adolescent idiopathic scoliosis: research progress |
| DENG Zixiang,NI Songzhi,LIU Xuan,LI Ming,BAI Yushu* |
(Department of Spinal Surgery, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity that occurs in adolescents aged 10-18 years. It is more common in female adolescents. Despite extensive research, the precise pathological mechanisms underlying AIS are yet to be fully elucidated. Given its links to abnormal bone growth and reduced bone mineral density, the involvement of mesenchymal stem cells (MSCs) in bone metabolic disorders is considered a plausible contributing factor of AIS. This review summarizes the role of MSCs in the pathogenesis of AIS and provides a forward-looking perspective on the potential clinical application. |
| Key words: mesenchymal stem cells adolescent idiopathic scoliosis pathogenesis bone metabolism |
