| 摘要: |
| 原发性肺冲击伤是爆炸产生冲击波直接作用于肺脏导致的急性肺损伤，严重者可发展为急性呼吸窘迫综合征，是导致作业人员死亡的重要原因之一。原发性肺冲击伤的病理生理特征相对明确，病理上主要表现为肺泡-毛细血管损伤和随之而来的肺出血、肺水肿，伴随氧化应激、细胞凋亡、炎症反应等生理过程，但分子机制有待进一步研究。本文就近年来原发性肺冲击伤中PI3K/Akt、NF-κB、MAPK等信号通路的研究进展进行综述。 |
| 关键词: 冲击伤 肺损伤 信号通路 磷酸肌醇3-激酶类 核因子κB 丝裂原活化蛋白激酶 |
| DOI：10.16781/j.CN31-2187/R.20220452 |
| 投稿时间：2022-05-31修订日期：2022-09-02 |
| 基金项目:海南省自然科学基金（824QN408）. |
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| Signaling pathways related to primary blast lung injury: research progress |
| ZHAO Songyun1,2,DIAO Chaoyue3,BAI Chong1* |
(1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Internal Medicine (Ⅰ), The Second Naval Hospital of PLA Southern Theater Command, Sanya 572000, Hainan, China;
3. Department of Endocrinology, No. 971 Hospital of PLA Navy, Qingdao 266000, Shandong, China
*Corresponding author) |
| Abstract: |
| Primary blast lung injury is an acute lung injury caused by the direct impact of explosive shock wave acting on the lung; the serious case can develop acute respiratory distress syndrome, which is one of the leading causes of mortality in blast injury personnel. The pathophysiological characteristics of primary lung blast injury are relatively clear: rupture of the alveolar capillaries and subsequent intrapulmonary haemorrhage and edema, accompanied by oxidative stress, apoptosis, inflammatory reaction and other physiological processes. However, the molecular mechanism needs to be further studied. This paper focuses on the research progress of phosphatidylinositol 3-kinase/protein kinase, nuclear factor κB, mitogen-activated protein kinase and other signaling pathways in the research of primary blast lung injury. |
| Key words: blast injury lung injury signaling pathway phosphatidylinositol 3-kinases nuclear factor κB mitogen-activated protein kinase |
