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无环鸟苷对K562细胞的抗增殖和诱导分化作用
孟沛霖,夏放,韩军,袁有忠,居小萍
0
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摘要:
目的:探讨无环鸟苷(ACV)对人白血病细胞的抗增殖和诱导分化作用。方法:将无环鸟苷加入K562细胞培养4 d,测定其活细胞数目、联苯胺染色阳性率,光镜观察形态、组织化学染色。结果:在ACV的作用下,K562细胞的增殖受抑,生长分数降低,并且向具有合成血红蛋白能力的细胞分化。结论:ACV对K562细胞具有抑制增殖和诱导分化作用,该结果可为慢性粒细胞白血病的治疗探索新的途径。
关键词:  无环鸟苷  慢性粒细胞白血病
DOI:
基金项目:
The effect of acycloguanosine on inhibiting proliferation and inducing differentiation of K562 cells
孟沛霖,夏放,韩军,袁有忠,居小萍
()
Abstract:
Objective: To explore whether acycloguanosine (ACV) can inhibit the proliferation and induce the erythrodifferentiation of human myeloid leukemia K562 cells. Methods: K562 cells were cultured with ACV for 4 d to detect cellular changes. Results: When K562 cells grew in a medium containing ACV, the cellular growth and division were gradually suppressed, growth fraction decreased and further differentiation towards the cell producing hemoglobins was found. Conclusion: ACV can inhibit proliferation and induce erythrodifferentiation of K562 cells.
Key words:  acycloguanosine  chronic myeloid leukemia