| 摘要: |
| 目的：探讨精神分裂症患者血清5种元素含量变化与疾病的关系。方法：采用原子吸收光谱法测定65例精神分裂症患者血清微量元素Zn,Cu,Fe和常量元素Ca,Mg含量的动态变化。结果：(1)精神分裂症患者血清Zn和Mg含量及Zn/Cu比值明显低于对照组，而Cu,Fe和Ca含量及Ca/Mg比值明显高于对照组。(2)病程＜3年的患者血清Ca含量明显高于病程3年以上患者(P＜0.01)；其他无明显差异(P＞0.05)。(3)经氯丙嗪等治疗14 d和21 d,患者Zn和Mg含量及Zn/Cu比值明显升高，而Cu,Fe和Ca含量及Ca/Mg比值明显降低。结论：精神分裂症患者可能存在Zn,Cu,Fe,Ca和Mg元素代谢异常，这些元素的代谢异常可能在本病的发生和发展中起一定作用。 |
| 关键词: 精神分裂症 血清 微量元素 常量元素、原子吸收光谱法 |
| DOI： |
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| 基金项目: |
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| Clinical observation of the changes of five elemental contents in serum in patients with schizophrenia |
| 刘龙林,姜永良,盛杏英,崔庶,余海鹰,盛华,赵德山,李东方,何邦平 |
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| Abstract: |
| Objective: To study the relation between the changes of five elemental contents in serum and schizophrenia. Methods: The dynamic changes of the trace elements Zn, Cu, Fe and ordinary elements Ca,Mg were examined in 65 patients with schizophrenia by atomic absorption spectrophotometer. Results: (1)The contents of Zn,Mg and Zn/Cu in patients with schizophrenia were significantly lower than those in controls, while Cu,Fe, Ca and Ca/Mg were significantly higher than those in controls.(2)The content of Ca in schizophrenic patients with course of disease ＜3 years was significantly higher than those ≥3 years.(3) After 14 and 21 d treatment with chlorpromazine or clozapine, the contents of Zn, Mg and Zn/Cu increased obviously, while Cu, Fe, Ca and Ca/Mg decreased obviously. Conclusion: These findings suggest that the patients with schizophrenia might have an abnormal serum Zn, Cu, Fe, Ca and Mg metabolism.This would play a role in causing and developing schizophrenia. |
| Key words: schizophrenics serum trace elements ordinary elements atomic absorption spectrophotometer |
