| 摘要: |
| 目的：研究维拉帕米、利舍平在淋球菌多重耐药性中的作用。方法：利用淋球菌快速定量药敏测试法对30株淋球菌进行药物敏感性检测。所测菌株包括WHO标准株，A，B，C，D，E株及临床分离株，6种抗生素分别加利舍平、维拉帕米，测定两者对淋球菌耐药性的影响。结果：一定浓度利舍平降低药物对淋球菌的最小抑菌浓度最多可达86％，而维拉帕米降低药物对淋球菌的最小抑菌浓度最多也可达81％。结论：利舍平和维拉帕米对淋球菌的多重耐药性具有一定的逆转作用，可降低抗生素对淋球菌最小抑菌浓度。 |
| 关键词: 淋球菌 抗生物敏感度 利舍平 维拉帕米 |
| DOI： |
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| 基金项目: |
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| The reverse effect of reserpine and verapamil on Neisseria gonorrhoeae′s multiple antibiotic resistance |
| 李志刚,廖万清,潘炜华 |
| () |
| Abstract: |
| Objective: To investigate the effect of reserpine and verapamil on Neisseria gonorrhoeae′s multiple antibiotic resistance. Methods: Rapid quantitative method of minimum inhibitory concentration(MIC) was used for susceptibility testing on 30 strains of N. gonorrhoeae, including standard strain of WHO, A,B,C,D,E strains and strains isolated from outpatients. The influences of reserpine and verapamil on N. gonorrhoeae′s multidrug resistance were tested after they were added to 6 antimicrobials, respectively. Results: A specific concentration of reserpine could reduce MIC of antimicrobials on N.gonorrhoeae strains by 86%,while verapamil by 81%. Conclusion: Reserpine and verapamil have reverse effect on N. gonorrhoeae′s multiple antibiotic resistance, both of them can reduce the antimicrobials′ MIC to N. gonorrhoeae. |
| Key words: Objective: To investigate the effect of reserpine and verapamil on Neisseria gonorrhoeae′s multiple antibiotic resistance. Methods: Rapid quantitative method of minimum inhibitory concentration(MIC) |
