| 摘要: |
| 目的：探讨施他宁对门脉高压性胃病(PHG)的治疗作用。方法：部分结扎大鼠门脉主干2周制作PHG模型,观察施他宁对PHG大鼠全身血流动力学、胃粘膜血流量(GMBF)、门脉压力(PVP)和胃粘膜下层血管的影响,测定了输注施他宁30 min后PHG大鼠血浆胰高糖素，血浆和胃粘膜 6-keto-PGF1α含量，并与普萘洛尔进行了对比。结果：施他宁和普萘洛尔均能降低PVP、GMBF， 而对胃粘膜下层血管无影响；施他宁能拮抗PHG大鼠胰高糖素作用、抑制胃酸和胃蛋白酶，对平均动脉压(MAP)和心率无明显影响，普萘洛尔与施他宁相反；普萘洛尔和施他宁两组均不能拮抗PGI2。结论：施他宁通过拮抗PHG大鼠胰高糖素的作用降低GMBF，且对外周循环无明显影响。 |
| 关键词: 门脉高压 胃疾病 施他宁 |
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| Study on stilamin in the treatment of portal hypertensive gastropathy in rats |
| 邓志坚,裘松祥,张兴荣,张贤康,乐桥良 |
| () |
| Abstract: |
| Objective: To observe the effects of stilamin on portal hypertensive gastropathy (PHG) in rats. Methods: Two weeks after portal vein ligation, the changes of hemodynamics, GMBF, PVP , and submucosal blood vessels were observed;plasma glucagon, plasma and gastric mucosal 6-keto-PGF1α were tested after intravenous stilamin, propranolol and saline. Results: GMBF and PVP were reduced whereas submucosal blood vessels were not changed after intravenous stilamin and propranolol.Stilamin decreased plasma glucagon,hindered gastric acid and pepsin secretion, had no effect on MAP and heart rate of PHG rats as compared with control group of PHG, whereas propranolol had no such effects, but it might decrease MAP and heart rate. There were no differences in plasma and gastric mucosal 6-keto-PGF1α levels between all PHG groups. Conclusion: Stilamin reduced GMBF of rats with PHG by hindering glucagon, and had no effect on hemodynamics. |
| Key words: portal hypertension stomach diseases stilamin |
