| 摘要: |
| 目的：观察内皮素A受体拮抗剂BQ610对猫急性心肌缺血性心律失常的影响,以探讨内皮素在急性缺血性心律失常发生中的作用。方法：结扎猫左冠状动脉前降支（LAD）起始段，造成急性心肌缺血，观察30 min缺血期内心律失常发生情况及LAD内注射BQ610对心律失常的影响。结果：BQ610呈剂量依赖性拮抗LAD结扎引起的猫急性缺血性心律失常。结论：内源性内皮素可能通过内皮素A受体参与致急性缺血性心律失常。 |
| 关键词: 内皮素、受体拮抗剂，内皮素 心律失常，急性缺血性 |
| DOI： |
|
| 基金项目: |
|
| Antagonism of BQ610 on acute myocardial ischemic arrhythmia in cats |
| 任安经,吴晋晖,李楠,朱宝旺,袁文俊,林丽 |
| () |
| Abstract: |
| Objective: To observe the effect of endothelin A receptor antagonist BQ610 on acute myocardial ischemic arrhythmia in cats and to study the role of endothelin in the development of acute ischemic arrhythmia. Methods: Acute myocardial ischemic arrhythmia was induced by the occlusion of the initial segment of left anterior descending part of the coronary artery. Arrhythmia during 30 min of the ischemia was observed and the effects of BQ610 on the arrhythmia was evaluated. Results: BQ610 dose-dependently antagonized the acute ischemic arrhythmia. Conclusion: Mediated by endothelin A receptor, endogenous endothelin may play an important role in the development of acute ischemic arrhythmia in cats. |
| Key words: endothelin receptors antagonism, endothelin arrhythmia,acute ischemic |
