| 摘要: |
| 目的：研究高血压和老化对冠状动脉结构和功能的影响。方法：以4，16，26，40，55周龄的自发性高血压大鼠(SHR)和同种系正常血压的京都种大鼠(WKY)为动物模型，离体灌注测定冠状动脉最大流量(MCF)，光镜下测量冠状动脉外径(OD)、内径(LD)、冠状动脉壁横截面积(CSA)及横截面积和内径比(CSA/LD)。结果：高血压可致冠状动脉LD显著下降，CSA和CSA/LD显著增大；老化对LD及OD<100 μm冠状动脉的CSA和CSA/LD无显著影响，但可致OD>100 μm冠状动脉的CSA和CSA/LD显著增大；高血压和老化可致MCF显著下降，MCF与OD>100 μm冠状动脉的CSA/LD呈显著直线负相关。结论：高血压和老化伴随有冠状动脉结构和功能的改变，OD>100 μm冠状动脉结构改变可能是冠状动脉功能改变的主要原因。 |
| 关键词: 高血压 衰老 冠状动脉 |
| DOI： |
|
| 基金项目: |
|
| The effects of hypertension and aging on coronary arteriolar remodeling |
| 陈思聪,张国元,冀凯宏,秦永文,杨向群,章同华,章建梁 |
| () |
| Abstract: |
| Objective: To study the effects of hypertension and aging on structure and function of coronary vasculature. Methods: Spontaneously hypertensive rats(SHR) and normotensive Wistar-Kyoto rats(WKY) strains at 4,16,26,40, and 55 weeks of age were studied. Maximal coronary flow(MCF) was measured using an isolated perfused rat heart model. Outer dimeter(OD), lumen dimeter(LD), cross-sectional area(CSA), and CSA/LD were analysed by computer. Results: LD demonstrated a significant hypertension related decline and was not effected by aging. CSA and CSA/LD in arterioles<100 μm demonstrated a significant hypertension-related increase and was not effected by aging. There was a significant hypertension- and age-related increase in CSA and CSA/LD in arterioles>100 μm. In addition, there was a significant hypertension- and age-related decline in MCF. The tight linear relation between CSA/LD in arterioles>100 μm and MCF. Conclusion: Both hypertension and aging are accompanied by structural and functional alterations of the cornoary vasculature. Structural alterations in arterioles>100 μm may be the main reason for MCF decrease. |
| Key words: hypertension aging coronary artery |
