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黄颜木素对HSC-T6细胞增殖和胶原合成的影响
钱定华,王杰松,张俊平,张珉
0
()
摘要:
目的:研究黄颜木素对激活的永生型大鼠肝储脂细胞--HSC-T6细胞增殖和胶原合成的影响。方法:细胞增殖采用结晶紫染色法检测,胶原合成采用3H-脯氨酸掺入法分析。结果:黄颜木素(6.25-50.00μmol/L)以剂量依赖方式显著抑制血小板源生长因子(PDGF)刺激的HSC-T6细胞增殖,并抑制转化生长因子β1(TGFβ1)诱导的细胞内胶原合成。结论:黄颜木素具有抑制激活的肝储脂细胞增殖和胶原合成的作用。
关键词:  黄颜木素  血小板源生长因子  转化生长因子β  肝硬化
DOI:
基金项目:
Effects of fisetin on proliferation and collagen synthesis of HSC-T6 cells
钱定华,王杰松,张俊平,张珉
()
Abstract:
Objective: To study the effects of fisetin on proliferation and collagen synthesis of immortalized rat hepatic stellate cell line:HSC-T6 cells . Methods: Cell proliferation was measured by crystal violet stain ing assay. Collagen synthesis was determined by 3H-proline incorporation. Results: Fisetin (6.25-50.00 μmol/L)markly inhibited PDGF-stim ulat ed proliferation and TGFβ1-stimulated collagen synthesis of HSC-T6 cells in a concentration-dependent manner. Conclusion: Fisetin could inhi bit actived hepatic lipocyte proliferation and collagen synthesis
Key words:  fisetin  platelet-derived growth factor  transforming growth f actor beta  liver cirrhosis