| 摘要: |
| 目的：评价奥氮平的抗精神病作用。方法：通过苯丙胺诱导的小鼠定向运动实验、5-HTP诱导的小鼠头部抽动实验、大鼠僵住症试验，对奥氮平进行药效学观察，并与氯氮平及氟哌啶醇的药效进行比较。结果：奥氮平(ig，ED505.88mg/kg)、氯氮平(ig，ED5037.16mg/kg)、氟哌啶醇(ig,ED500.74mg/kg)能显著地拮抗苯丙胺诱导的小鼠定向运动，且有明显的量效关系。奥氮平(ig,ED500.54mg/kg)、氯氮平(ig，ED503.10mg/kg)、氟哌啶醇(ig,ED500.71mg/kg)能明显地拮抗5-HTP诱导的小鼠头部抽动。大鼠僵住症实验中，奥氮平、氯氮平、氟哌啶醇的ig,ED50分别是26,149,0.54mg/kg。结论：奥氮平有拮抗多巴胺及5-HT的活性，且其拮抗5-HT的作用比拮抗多巴胺的作用强，奥氮平的锥体外系不良反应轻，是一较好的抗精神病药物，奥氮平与氟哌啶醇合用对一些患者可能是较好的治疗方案。 |
| 关键词: 奥氮平 抗精神病药 |
| DOI： |
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| 基金项目: |
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| The antipsychotic effects of olanzapine |
| 陆国才 |
| () |
| Abstract: |
| Objective: To evaluate the antipsychotic effects of olanzapine. Methods: The effects of olanzapine on amphetamine induced forced action and 5-hydroxytryptophan (5-HTP) induced head twitches were observed in mice. The experiments of catalepsy induced by olanzapine were carried out in r ats. The results were compared with those of clozapine and haloperidol. Results: Olanzapine (2.4-9.6 mg/kg, ig, ED50 5.88 mg/kg), clozapin e (12-48 mg/kg, ig, ED50 37.16 mg/kg), haloperidol (0.225-0.900 mg/kg , ig, ED50 0.74 mg/kg) could significantly antagonize amphetamine-induced f orced action in mice in dose-dependent manner. Olanzapine (0.3-1.2 mg/kg, ig, ED50 0.54 mg/kg), clozapine (1.5-6.0 mg/kg, ig, ED50 3.10 mg/kg), haloperidol (0.225-0.900 mg/kg, ig, ED50 0.71 mg/kg) coul d significantly antagonize 5-HTP induced head twitches in mice. In rats cataleps y tests, the ig, ED50 of olanzapine, clozapine, haloperidol were 26, 149, 0.54 mg/kg, respectively. Conclusion: Olanzapine possesses dopa mine and 5-HT antagonist activity in vivo, and was a more potent 5-HT anta gonist than dopamine antagonist. Olanzapine has a low property for producing ex trapyramidal symptoms. Olanzapine is expected to find a place as a valuable alt ernative in classical antipsychotics. The combination of olanzapine and haloper idol may be a good recipe for some patients. |
| Key words: olanzapine antipsychotics |
