| 摘要: |
| 目的:研究不同人群中红细胞CR1基因组密度多型性与红细胞免疫粘附肿瘤细胞能力的相关性。方法:采用PCR加HindⅢ酶切技术测定红细胞CR1基因组密度多型性(HH型、HL型、LL型),采用肿瘤红细胞花环试验测定红细胞免疫粘附肿瘤细胞的能力。结果:在不同人群中,HH型红细胞免疫粘附肿瘤细胞的能力明显大于HL型红细胞,而HL型红细胞免疫粘附肿瘤细胞的能力明显大于LL型红细胞。结论:红细胞免疫粘附肿瘤细胞的能力与CR1基因组密度多型性有关。 |
| 关键词: 受体，红细胞 肿瘤细胞粘附 基因组密度多型性 |
| DOI： |
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| 基金项目: |
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| Studies on correlation between CR1 genomic density polymorphism of erythrocytes and ability of immune adhering to tumour cells |
| 叶芳耘,张乐之,赵书平,郭峰 |
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| Abstract: |
| Objective: To study correlation between CR1 genomic density polymorphism of erythrocytes and ability of erythrocytes adhering to tumour cells in variant population(normal people, patient with HBV infection, with hepatoc irrhosis and with hepatocarcinoma).Methods: Genomic determination of the CR1 density polymorphism (HH type, HL type, LL type) of erythrocytes was p erformed using polymerase chain reaction amplification and Hind Ⅲ retriction e nzyme digestion. Ability of erythrocytes adhering to tumour cells using tumour erythrocyte rosetest. Results: In different population,ability of HH type erythrocytes adhering to tumour cells was significantly higher than that of HL type erythrocytes. Ability of HL type erythrocytes adhering to tumour cells was significantly higher than that of LL type erythrocytes. In same CR1 genomic type population, ability of erythrocytes adhering to tumour cells in normal p eople significantly higher than that in patients with HBV infection and patients with hepatocirrhosis and patients with hepatocarcinoma. Conclusion: These results indicate that activity of erythrocytes adhering to tumour cells may be related to CR1 genomic density polymorphism type. |
| Key words: receptors, erythrocytes tumor cells adhesion genomic density polymorphism |
