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食管癌患者放疗前后血清转化生长因子β1的变化及临床意义
余友渔,兰莉,董昭,金冶宁,孙苏平
0
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摘要:
目的 探讨食管癌放疗前后血清转化生长因子β1(TGFβ1)水平改变与放疗疗效及预后的关系。方法:采用ELISA方法检测56例明确诊断的食管癌患者放疗前后的血清TGF β1水平,并将其与病变范围、部位、X线病理分型、近期疗效及转移复发的关系进行对比分析。结果:放疗前食管癌患者血清TGF β1平均水平明显高于正常对照组(P<0.01),血清TGF β1的表达与病变部位、病变长度、X线病理分型无关(P>0.05);放疗后血清TGF β1水平下降(P<0.05),其改变与近期疗效及转移复发相关(P<0.01)。结论:血清TGF β1水平可作为监测食管癌近期放疗疗效和预后、提示后续或辅助治疗的一项参考指标。
关键词:  食管肿瘤  转化生长因子β1  放射疗法
DOI:
基金项目:
The clinic significance of the changes of serum transforming growth factor β1 before and after radiotherapy in esophageal carcinoma patients
余友渔,兰莉,董昭,金冶宁,孙苏平
()
Abstract:
Objective: To evaluate the relation between the changes of serum transforming growth factor beta1 (TGFβ1) and response to radiotherapy in esophageal carcinoma before and after radiotherapy. Methods: Fifty six newly diagnosed esophageal carcinoma patients were studied. Serum samples for TGFβ1 were obtained before and after radiotherapy. An enzyme-lined immunosorbent assay(ELISA) was used to measure changes of serum TGFβ1 levels and compared with the limits, location, X-ray pathologic, the immediate response to radiotherapy, metastasis and recurrence. Results: The data showed that the serum TGFβ1 level in esophageal carcinoma patients before radiotherapy was significantly higher than that of healthy controls(P<0.01).The changes of serum levels after radiotherapy were also closely related to the limits, the immediate response to radiotherapy and metastasis and recurrence(P<0.01), but were not related to the location, X-ray pathological pattern of the lesions. Conclusion: These results suggest that the serum TGFβ1 level may be a useful marker for monitoring the response and prognosis after radiotherapy in patients with esophageal carcinoma.
Key words:  esophageal neoplasms  transforming growth factor beta1  radiotherapy