| 摘要: |
| 目的：研究内皮素受体拮抗剂PD142893对大鼠损伤脊髓血流及功能的影响，探讨内皮素在继发性脊髓损伤中的作用机制。方法：35 g物体后路压迫大鼠胸段脊髓5 min造成脊髓急性中度损伤。应用激光多普勒血流仪检测对照组、损伤组及PD142893治疗组(蛛网膜下腔注射给药50 μg)大鼠局部脊髓血流的动态变化，并观察伤后一周的神经功能恢复情况。结果：PD142893蛛网膜下腔注射能明显改善脊髓压迫伤早期（30 min至8 h）的低血流灌注;且能部分恢复损伤大鼠脊髓功能。结论：内皮素可能是脊髓继发性损伤的重要损害因子之一; 蛛网膜下腔注射内皮素受体拮抗剂PD142893能部分逆转脊髓损伤。 |
| 关键词: 脊髓损伤 内皮素 受体拮抗剂，内皮素 脊髓血流 |
| DOI： |
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| 基金项目: |
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| The effect of endothelin receptor antagonist PD142893 on blood flow and function of injuried spinal cord in rats |
| 傅强,侯铁胜,鲁凯伍 |
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| Abstract: |
| Objective: To observe the effect of endothelin receptor antagonist on blood flow and function of injuried spinal cord in rats and explore mechanisms of ET in spinal cord injury (SCI). Methods: The thoracic spinal cord of rats was compressed by a load of 35 g for 5 min, which caused moderate injury. The rats were assigned into 3 groups: control group, injuried group, PD142893 group. The changes of spinal cord blood flow (SCBF) were measured by way of Laser Doppler flowmetry during 8 hours and the neurological function of injuried rats was evaluated one week after spinal cord injury. Results: PD142893 significantly increased early SCBF at compression sites after SCI by intrathecal injection and partly restored the motor function of the damaged spinal cord. Conclusion: ET plays a key role in secondary injury after acute spinal cord injury and that intrathecal injection of ET receptor antagonist PD142893 can partly reverse the progression of SCI. |
| Key words: spinal cord injuries endothelial receptor antagonist endothelin spinal cord blood flow |
