| 摘要: |
| 目的：探讨药物对颅脑伤后血糖水平的影响。方法：采用颅脑外伤液压致伤装置制作颅脑伤动物模型，动态观察药物对血糖水平的影响。结果：(1)地塞米松＋10％葡萄糖＋胰岛素药物组和地塞米松＋20％甘露醇＋胰岛素组，对颅脑伤后的高血糖具有治疗作用。(2)单纯应用20％甘露醇，在72 h内对颅脑伤大鼠具显著的降血糖作用。(3)纳络酮能够显著降低颅脑伤大鼠的血糖含量，给药后24 h作用最为显著，72 h时仍能维持很好的疗效。结论：甘露醇、纳络酮和适度的pH值，对颅脑伤动物具有降血糖作用。 |
| 关键词: 脑损伤 血糖 |
| DOI： |
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| 基金项目: |
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| Relationship between the drugs and blood sugar after brain injury in rats |
| 周玉璞,江基尧,张光霁,朱诚,路红社 |
| () |
| Abstract: |
| Objectve: To study the relationship between the drugs and blood sugar(BS) after brain injury. Methods: The effect of usual drugs which treating brain injury(BI) on BS was observed in rats after head injury.Results: (1)The group of dexamethasonum ＋ 10％ glucose ＋ insulin, and the group of dexamethasonum ＋ 20％ mannitolum ＋ insulin were effective for treating high BS after drug injection. (2)20％ mannitolum was effective for treating high BS after drug injection. (3)Naloxone could markedly decrease BS. Conclusion: The drugs of mannitolum, naloxone and certain pH could decrease blood sugar in brain injury animals |
| Key words: brain injuries blood sugar |
