| 摘要: |
| 目的：探讨21-氨基类固醇类药物U-74389G对脑外伤后脑水肿和离子含量的影响。方法：分别采用干/湿质量法测定伤后脑含水量，原子吸收光谱分析法测定脑组织内离子含量。结果：伤侧脑组织含水量外伤组较对照组显著增加，但治疗组含水量比外伤组又显著降低。Na+、Ca2+含量外伤组较对照组明显增加，但治疗组比外伤组显著降低；K+、Mg2+含量外伤组较对照组明显降低，但治疗组较外伤组有不同程度的升高。结论：U-74389G能有效地减轻脑外伤后脑水肿 |
| 关键词: 21-氨基类固醇 脑水肿 |
| DOI： |
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| 基金项目: |
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| Effect of 21-aminosteroid (U-74389G) on brain edema post traumatic brain injury in rats |
| 于明琨,江基尧,杨中坚,卢亦成,陈世文 |
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| Abstract: |
| Objective: To explore the effect of 21-aminosteroid (U-74389G) on brain edema post traumatic brain injury (TBI) in rats. Methods: Water content of brain after TBI was assayed by means of dry/wet weight methodology, and the content of ion was measured by an atom absorption spectrum analysis apparatus. Results: The turbulence of sodium, potassium, calcium and magnesium after TBI could be alleviated by U-74389G. The increased water content of injured brain tissue could also be alleviated by the administration of U-74389G. Conclusion: The study indicates that U-74389G could effectively improve brain edema after TBI |
| Key words: 21-aminosteroid brain edema |
