| 摘要: |
| 目的：探讨生长抑素(somatostatin,SS)及氧化苦参碱(oxymatrine,Oxy)对大鼠急性胰腺炎(AP)的治疗作用及其机制。方法： 由蛙皮素皮下注射诱导大鼠AP，随后予静脉输注SS及腹腔内注射Oxy。结果: 与AP组相比，SS及Oxy治疗组大鼠胰腺/体质量值明显下降，血清淀粉酶及胰腺组织病理学改变明显改善， 血清及胰腺组织内IL-1、IL-6、TNFα等炎性细胞因子水平显著降低(均P<0.01)。结论： SS及Oxy对实验性大鼠AP具有良好治疗效果，其机制可能与其抑制炎性细胞因子的产生有关。 |
| 关键词: 生长抑素 氧化苦参碱 胰腺炎，急性 |
| DOI： |
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| 基金项目: |
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| Treatment of acute pancreatitis with somatostatin and oxymatrine in rats |
| 马述春,张兴荣,魏立民 |
| () |
| Abstract: |
| Objective:：To investigate the therapeutic effects of somatostatin(SS) and oxymatrine(Oxy) on experimental pancreatitis and their mechanisms. Methods: Acute experimental pancreatitis rats were induced with supramaximal dosage of caerulein injected subcutaneously. The treatment group administered with SS intravenously and Oxy i.p.,and related parameters were examined. Results: Compared with acute pancreatitis group, pancreatic mass, edema, inflammatory cell infiltration and serum amylase were significantly reduced in SS or Oxy treatment group.Besides,the inflammatory cytokines in serum or pancreatic tissue were both significantly decreased(P<0.01). Conclusion:SS and Oxy have beneficial effects on treatment of experimental acute pancreatitis. The mechanism maybe related to inhibiting the releasing and activity of inflammatory cytokines |
| Key words: somatostatin oxymatrine pancretitis,acute |
