| 摘要: |
| 目的：研究一类新型的三氮唑化合物对念珠菌属真菌的抗真菌活性。方法：采用体外抗真菌活性试验, 测定化合物的最低抑菌浓度(MIC)，从而评价化合物的生物活性作用。结果：所有24个新的化合物对念珠菌属真菌均有不同的抑制作用，其中对白念珠菌的活性最好。化合物12对白念珠菌的活性最强，是标准对照品氟康唑的256倍。化合物17对耐氟康唑的白念珠菌的活性最强，是标准对照品氟康唑的16倍。结论：化合物12和17可以作为两个潜在的药物进一步进行研究。 |
| 关键词: 三氮唑化合物、念珠菌属、抗真菌活性 |
| DOI： |
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| Antifungal activity of new triazole compounds against candida species |
| 吕加国,朱驹,李科,周有骏,张万年,钟武 |
| () |
| Abstract: |
| Objective： To study the antifungal activity of the new triazole compounds against candida species. Methods: The MICs of new triazole compounds were determined in in vitro antifungal tests to evaluate the activities of title compounds. Results: All new triazole compounds had activity against candida species, especially high activity against candida albicans. Compound 12 exhibited remarkably high efficacy and was 256 times more active than fluconazole against candida albicans. Compound 17 was the most effective agent against fluconazole-resistant candida albicans and was 16 times more active than fluconazole. Conclusion: The 2 compounds are worth advanced studying as potential drugs. |
| Key words: triazoles candida antifungal activity |
