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病毒性肝炎患者血浆神经肽的变化及其临床意义
韩絮琳,秦一中,万谟彬,杨正德
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摘要:
目的:探讨病毒性肝炎患者血浆神经肽的变化规律及其意义。方法:用放射免疫法(RIA)检测了67例各型肝炎患者及10名正常人血浆亮啡肽、神经肽Y含量。结果:各型肝炎患者急性肝炎、慢重肝、慢肝重度和中度血浆亮啡肽含量显著高于正常对照组(P<0.05),且慢重肝和慢肝重度显著高于其他各组(P<0.01)。神经肽Y显著低于慢肝轻度和正常对照组(P<0.01)。在慢性肝病者中,血浆亮啡肽与血清总胆红素呈正相关,与清蛋白和凝血酶原活动度呈负相关,而神经肽Y与之相反。结论:病毒性肝炎患者血浆亮啡肽显著升高,而神经肽Y显著降低,并与肝损害程度基本一致。推测该两种神经肽可能参与了病毒性肝炎的病理损害过程,并与某些临床症状有关,可作为评价肝功能的一项辅助指标。
关键词:  肝炎,病毒性  亮啡肽  神经肽Y
DOI:
基金项目:
Study on the levels of plasma leucineenkephalin and neuropeptide Y in patients with viral hepatitis
韩絮琳,秦一中,万谟彬,杨正德
()
Abstract:
Objective:To assess the clinical significance of plasma neuropeptides in patients with viral hepatitis. Methods: Levels of plasma leucinenkephalin (LENK) and neuropeptide Y (NPY) were detected with radioimmunoassay in 67 patients with hepatitis and 10 healthy controls. Results: The level of LENK in patients was significantly higher than that in controls (P<0.05). In patients with hepatitis, the level of LENK was higher in chronic hepatic failure and chronic hepatitis (severe) than that in the rest (P<0.01). The concentration of LENK was positively correlative with serum total bilirubin (TBIL) (r=0.43, P<0.01), but negatively correlative with serum albumin (ALB) (r=-0.25, P<0.05) and prothrombin time activity (PA) (r=-0.55, P<0.01). The levels of NPY in chronic hepatic failure and chronic hepatitis (severe and medium) were significantly lower than that in other viral hepatitis groups and healthy controls (P<0.01). The concentration of plasma NPY in chronic hepatitis was negatively correlated with TBIL (r=-0.34, P<0.01), but postively correlated with ALB and PA (each r=0.38, P<0.01). Conclusion: Plasma LENK and NPY levels may be used as an associated marker for judging liver function. They may contribute to the pathogenesis of viral hepatitis and some of its symptoms.
Key words:  hepatitis,viral  leucineenkephalin  neuropeptide Y