| 摘要: |
| 肠神经系统由肠道肌间神经丛和黏膜下神经丛组成，肌间神经丛主要控制肠道的运动，黏膜下神经丛主要调节胃肠分泌和局部血流。二者都存在P2(ATP)受体，它们在生理和病理情况下介导不同的效应。本文主要就目前已知的肠神经系统内P2受体的分布、作用及特性作一综述，为进一步探讨P2受体在肠道疾病诊治中的作用提供依据。 |
| 关键词: 肠神经系统 肌间神经丛 黏膜下神经丛 ATP受体 肠道疾病 |
| DOI：10.3724/SP.J.1008.2008.00095 |
| 投稿时间：2007-06-15 |
| 基金项目:国家自然科学基金面上项目（30970597）. |
|
| Distribution and properties of P2 receptors in enteric nervous system |
| ZHOU Mingyue1,2, MA Bei2* |
| (1. Faculty of Naval Medicine,Second Military Medical University, Shanghai 200433,China; 2. Department of Physiology,College of Basic Medical Sciences,Second Military Medical University, Shanghai 200433) |
| Abstract: |
| Enteric nervous system consists of myenteric and submucous plexuses. Myenteric plexus mainly innervates the enteric motion; submucous plexus modulates the gastrointestinal secretion and local blood flow. P2 (ATP) receptors exist in both of the above plexuses and play an important role under physiological and pathophysiological conditions. This article reviews the distribution, function and pharmacological characteristics of different P2 receptors, in an effort to provide new evidence for studying the role of P2 receptors in the diagnosis and therapy of enteric diseases. |
| Key words: enteric nervous system myenteric plexus submucous plexus ATP receptors enteric diseases |
