| 摘要: |
| 目的：评价活体肾移植供肾者术后长期安全性。方法：随访26例活体肾移植供者术后2～8（4.27±2.11）年血肌酐、血压、尿蛋白的变化，并评价供肾对供者心理学的影响。结果：供者术后血肌酐较术前明显升高（P＜0.01），但仍在正常范围内，且一直稳定在一定水平；供者术后血压与术前相比无明显差异；1例供者在术后1个月复查发现微量蛋白尿，经休息后好转，其他供者尿常规检查均为阴性；无1例死亡。1例供者对当初供肾行为表示后悔，觉得供肾对自己带来了一定的心理压力。结论：对于健康供者而言，无偿捐献一侧肾脏是安全可行的，不会给供者带来明显的生命威胁及心理负担，但术前对供者进行安全性评估及术后长期随访是十分必要的。 |
| 关键词: 肾移植 供者 安全性 |
| DOI：10.3724/SP.J.1008.2008.00555 |
| 投稿时间：2007-11-09修订日期：2008-03-20 |
| 基金项目: |
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| Long-term safety follow-up of living kidney donors: a report of 26 cases |
| HAN Shu1△, MIN Min2△,ZHAO Wen-yu1,WANG Li-ming1* |
| (1.Organ Transplantation Institute, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China;2.Department of Kidney Transplantation, Central Hospital of Zhabei District, Shanghai 200070) |
| Abstract: |
| Objective:To evaluate the long-term safety of living kidney donors after nephrectomy. Methods:Twenty-six living donors of kidney were followed up for 2-8 years, with a mean of (4.27±2.11) years. The serum creatinine, blood pressure, proteinuria and psychological stress were observed in the donors during follow-up.Results: The serum creatinine had a significant increase after nephrectomy（P＜0.01）,but all had normal serum creatinine levels and remained stable thereafter. There was no significant change in blood pressure or proteinuria after nephrectomy;only one case developed microalbuminuria after nephrectomy.One of the donors regretted donation and felt more mental stress after nephrectomy. All of the donors were alive without complications.Conclusion: Pre-operation assessment and selection of donors, along with standard intra-operation management and long-term post-operation follow-up, can guarantee the safety of the donors. |
| Key words: kidney transplantation living donors safety |
