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  • 季君,高春芳*.α 1,6岩藻糖基转移酶与肿瘤[J].第二军医大学学报,2011,32(2):209-213    [点击复制]
  • JI Jun, GAO Chun-fang*.α1, 6 fucosyltransferase and tumor: recent progress[J].Acad J Sec Mil Med Univ,2011,32(2):209-213   [点击复制]
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α 1,6岩藻糖基转移酶与肿瘤
季君,高春芳*
0
(第二军医大学东方肝胆外科医院实验诊断科,上海 200438)
摘要:
\[摘要\] 由α1,6岩藻糖基转移酶(α1,6fucosyltransferase,Fut8)催化的核心岩藻糖基化是糖蛋白重要的翻译后修饰和功能调控方式,直接影响细胞一系列生物学特性,而这种糖基化的异常改变往往是疾病状态的特点。本文就Fut8的表达调控特征、生物学功能及其与各种肿瘤的关系研究进展作一综述。
关键词:  α 1,6岩藻糖基转移酶  基因  肿瘤
DOI:10.3724/SP.J.1008.2011.0209
投稿时间:2009-11-02修订日期:2010-12-09
基金项目:国家自然科学基金(30971345),上海市优秀学科带头人计划(09XD1405800).
α1, 6 fucosyltransferase and tumor: recent progress
JI Jun, GAO Chun-fang*
(Department of Laboratory Diagnosis,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University, Shanghai 200438, China)
Abstract:
\[Abstract\] Core fucose glycosylation catalyzed by α1, 6fucosetransferase(Fut8) is an important way for protein posttranslational modification and functional regulation; it directly influences a series of biological characteristics of cells and is always seen under some pathological conditions. This paper reviews the recent studies on the regulation, biological function of Fut8 and its relationship with different kinds of tumors.
Key words:  α1, 6 fucosyltransferase  genes  neoplasms