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  • 余琛琳,刘志学,汤球,马雷,蔡丽萍,徐晨,崔淑芳.小型猪腹壁拉链模型动物的麻醉效果观测[J].第二军医大学学报,2012,33(2):224-229    [点击复制]
  • YU Chen-lin,LIU Zhi-xue,TANG Qiu,MA Lei,CAI Li-ping,XU Chen,CUI Shu-fang.Observation of anesthetic effect in abdominal zipper model with miniature pigs[J].Acad J Sec Mil Med Univ,2012,33(2):224-229   [点击复制]
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小型猪腹壁拉链模型动物的麻醉效果观测
余琛琳,刘志学,汤球,马雷,蔡丽萍,徐晨,崔淑芳*
0
(第二军医大学训练部实验动物中心,上海 200433
*通信作者)
摘要:
目的 研究速眠新Ⅱ和戊巴比妥钠联合麻醉法对小型猪腹壁拉链模型动物的麻醉效果,探讨小型猪腹壁拉链模型动物安全、可靠的麻醉方法 。方法 采用速眠新Ⅱ(0.1 ml/kg)肌内注射和3%戊巴比妥钠生理盐水溶液(0.2 ml/kg)静脉注射联合麻醉法对12只小型猪腹壁拉链模型动物进行麻醉,观察动物的基础生理指标、生物反射指标、镇静、镇痛和肌松效果以及麻醉维持时间。结果 静脉注射麻醉后15 min内,所有小型猪腹壁拉链模型动物的眼睑反射、角膜反射和肛门反射均消失,进入良好的镇静、镇痛和肌松状态,并持续至75 min;诱导期为(6.22±0.84) min,麻醉期为(79.9±3.6) min,苏醒期为(66.1±3.7) min,提供了长达80 min的良好麻醉时间。结论 肌内注射速眠新Ⅱ和静脉注射戊巴比妥钠联合麻醉法应用于小型猪腹壁拉链模型动物的麻醉,具有操作简便、镇静、镇痛、肌松效果好、用药量小、安全可靠等优点,是一种较为理想的麻醉方法 。
关键词:  小型猪腹壁拉链模型动物  麻醉  速眠新Ⅱ  戊巴比妥
DOI:10.3724/SP.J.1008.2012.0224
投稿时间:2011-06-11修订日期:2011-12-08
基金项目:上海市科技发展基金(08140901400,09140903100).
Observation of anesthetic effect in abdominal zipper model with miniature pigs
YU Chen-lin,LIU Zhi-xue,TANG Qiu,MA Lei,CAI Li-ping,XU Chen,CUI Shu-fang*
(Laboratory Animal Center, The Training Department, Second Military Medical University, Shanghai 200433, China
*Corresponding author.)
Abstract:
Objective To study the anesthetic effect of Sumianxin Ⅱ combined with pentobarbital sodium on the abdominal zipper model with miniature pigs, so as to explore a safe and reliable anesthetic method for establishing abdominal zipper model with miniature pigs.Methods Abdominal zipper models were induced with 12 miniature pigs by anesthesia with Sumianxin Ⅱ (0.1 ml/kg, im) and pentobarbital sodium(0.2 ml/kg, iv). The physiological parameter, eyelid reflex, corneal reflex, anal reflex, sedation effect, analgesic effect, muscle relaxant effect, and anesthesia duration were all observed.Results The eyelid reflex, corneal reflex and anal reflex of the 12 miniature pigs disappeared 15 min after intravenous anesthesia; and all the animals were in a good sedation, analgesia and muscle relaxation state, which maintained for 75 min. The induction period of anesthesia was (6.22±0.84) min, anesthesia duration was (79.9±3.6) min, and analepsia period was (66.1±3.7) min, providing a satisfactory anesthesia period of more than 80 min.Conclusion Intravenous Sumianxin Ⅱcombined with intramuscular pentobarbital sodium is a simple, safe, effective and reliable method for establishing abdominal zipper model with miniature pigs.
Key words:  animal model of miniature pig with abdominal zipper  anesthesia  sumianxin Ⅱ  pentobarbital