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| 中国南海黑乳海参共附生真菌Phialemonium sp.次生代谢产物的鉴定 |
| 王旭东1,孙鹏2,许东啸2,汤华2,刘宝姝2,张文2* |
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(1. 解放军第425医院药械科, 三亚 572000;
2. 第二军医大学药学院海洋药物研究中心, 上海 200433*通信作者) |
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| 摘要: |
| 目的 对中国南海黑乳海参的共附生单胞瓶霉属真菌（Phialemonium sp.）的次生代谢产物进行研究。方法 运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱等分离手段对真菌Phialemonium sp.的乙酸乙酯提取物进行分离纯化，利用现代波谱技术并结合文献报道进行结构鉴定。结果 分离得到2个缩酚酸环醚化合物emeguisin A和aspergillusidone C。结论 作为黑乳海参共附生真菌Phialemonium sp.次生代谢产物，2个化合物均为首次从该真菌中分离得到。 |
| 关键词: 黑乳海参 海参共附生真菌 单胞瓶霉属 缩酚酸环醚 |
| DOI：10.3724/SP.J.1008.2014.00988 |
| 投稿时间：2014-07-01修订日期：2014-09-11 |
| 基金项目:国家自然科学基金（30873200，41176125，81202453）；上海浦江人才计划（PJ2008）；海南省自然科学基金（811223）；三亚市医疗卫生科技创新项目（YW1228）. |
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| Identification of secondary metabolites of the fungus Phialemonium sp. associated with the South China Sea cucumber Holothuria nobilis Selenka |
| WANG Xu-dong1,SUN Peng2,XU Dong-xiao2,TANG Hua2,LIU Bao-shu2,ZHANG Wen2* |
(1. Drug and Equipment Section, No. 425 Hospital of PLA, Sanya 572000, Hainan, China;
2. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
* Corresponding author.) |
| Abstract: |
| Objective To investigate the secondary metabolites of the fungus Phialemonium sp. associated with the South China Sea cucumber Holothuria nobilis Selenka. Methods The EtOAc extract of Phialemonium sp. was purified by repeated column chromatography on silica gel, Sephadex LH-20, and high-performance liquid chromatography (HPLC). Structural determination of the isolated compounds was achieved by spectroscopic analysis and by comparison with previously reported data. Results Two depsidones were isolated and their structures were determined as: emeguisin A and aspergillusidone C. Conclusion This is the first report on the secondary metabolites of Phialemonium sp. associated with the sea cucumber H. nobilis Selenka, and the two depsidones are reported for the first time from the fungus strain Phialemonium sp. |
| Key words: Holothuria nobilis Selenka sea cucumber associated fungus Phialemonium sp. depsidone |
