| 摘要: |
| 乙肝病毒(HBV)基因与宿主肝细胞基因组发生整合是肝细胞癌(HCC)进化过程中的常见现象。HBV慢性感染导致HBV变异、HBV整合以及宿主体内炎症微环境改变, 这些改变为HCC的发生和发展提供了进化“土壤”。近期兴起的二代测序技术为了解HCC中HBV的整合机制提供了更好的途径。本文就HBV整合特点和方式, 及整合对宿主、病毒基因组的影响等方面进行总结, 并阐述HBV整合与HCC致癌的相关性。 |
| 关键词: 乙型肝炎病毒 基因整合 肝细胞癌 进化 |
| DOI：10.3724/SP.J.1008.2014.01299 |
| 投稿时间：2014-09-23修订日期：2014-11-01 |
| 基金项目:国家重点基础研究发展计划(“973”计划, 2015CB554000). |
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| Role of hepatitis B virus integration in evolution of hepatocellular carcinoma |
| JI Xiao-wei1,NIU Jia-xin2,CHEN Xi1,CAO Guang-wen1* |
(1. Department of Epidemiology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China;
2. The 5th Student Brigade, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Hepatitis B virus (HBV)-human DNA integration is a commonly seen event in the evolutionary process of hepatocellular carcinoma (HCC). HBV chronic infection induces HBV mutation, HBV integration and the inflammatory microenvironment alternation in the hosts, which provides a evolutionary soil for the hepatocarcinogenesis. The second generation sequencing technique provides a better approach for understanding the HBV integration mechanism in HCC. This review focuses on the features of HBV integration and influences of HBV integration on human, virus genomes, and discusses the association of HBV integration with HCC. |
| Key words: hepatitis B virus virus integration hepatocellular carcinoma evolution |
