| 摘要: |
| 神经干细胞移植替代治疗已经成为治疗中枢神经损伤的一个重要手段,但其细胞来源由于伦理学和免疫排斥等问题而受到了限制。既往研究认为,非神经细胞不能转变成神经细胞。但诱导型多潜能干细胞出现之后,研究发现,通过细胞基因重编程技术可以将鼠和人的自身体细胞诱导转分化为神经干细胞或各种类型的神经元,从而避免了细胞移植治疗中相关的伦理学问题和免疫排斥反应,表明细胞基因重编程在中枢神经损伤修复中具有很好的应用前景。本文对细胞基因重编程技术在诱导神经干细胞或神经元形成方面的相关研究进展及其在中枢神经损伤修复中的应用进行了综述。 |
| 关键词: 中枢神经系统 重编程 神经退行性疾病 神经损伤 细胞移植 |
| DOI：10.16781/j.0258-879x.2016.06.0729 |
| 投稿时间：2015-11-13修订日期：2016-01-05 |
| 基金项目:国家自然科学基金(81271352),上海市科技创新行动计划(15JC1400202),上海市浦江人才计划(15PJ1410500). |
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| Application of cell lineage reprogramming for central nervous system injury and repair |
| SUN Xiu,YUAN Yi-min,HU Xin,QIN Shang-yao,SU Zhi-da |
(Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Transplantation of neural stem cells (NSCs) has become an important therapeutic strategy for central nervous system (CNS) injury; however, the potential immune rejection and ethical concerns limit the transplantation-based cell therapy in clinic. Alternatively, induced pluripotent stem cells (iPSCs) may overcome these major hurdles and cast new lights on cell therapy. Recent studies have shown that a variety of somatic cells from mouse or human can be reprogrammed into NSCs or neurons, suggesting that reprogramming of cell fate may represent a promising strategy for CNS repair. Here, we reviewed the current knowledge of cell lineage reprogramming, reprogramming-mediated induction of NSCs or neurons and their application in CNS repair. |
| Key words: central nervous system reprogramming neurodegenerative disease neurotrauma cell transplantation |
