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| Hippo信号通路在成骨代谢中的研究进展 |
| 段煜东,张子程,李博,程亚军,陈绍丰,李明,周潇逸*,魏显招 |
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(海军军医大学(第二军医大学)长海医院骨科, 上海 200433
*通信作者) |
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| 摘要: |
| 人体的骨骼组织在正常情况下总是处于不断磨损和重建的过程中，并保持一定的稳定性，但在遭受外力如挤压、冲击、手术时会发生骨裂、骨折和骨不连，全身骨骼的系统稳态被打破。为了恢复正常的解剖结构和功能，机体通过诱导成骨、抑制凋亡等方式促进成骨代谢、修复骨创伤。Hippo通路是细胞内外信号传递的有效途径之一，调节细胞增殖、分化进程，在成骨代谢中发挥重要作用。本文就此进行综述，以期为探索其潜在机制指明方向。 |
| 关键词: Hippo信号通路 Yes相关蛋白 间充质干细胞 成骨细胞 |
| DOI：10.16781/j.0258-879x.2021.03.0314 |
| 投稿时间：2020-08-07修订日期：2020-09-27 |
| 基金项目:国家自然科学基金（81900809），上海市卫生健康委员会卫生行业临床研究专项（20194Y0232），上海市卫生系统优秀人才培养计划（2018YQ26）. |
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| Hippo signaling pathway in osteogenic metabolism: research progress |
| DUAN Yu-dong,ZHANG Zi-cheng,LI Bo,CHENG Ya-jun,CHEN Shao-feng,LI Ming,ZHOU Xiao-yi*,WEI Xian-zhao |
(Department of Orthopaedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Human bone tissue is always in the processes of continuous wearing and reconstruction with a certain stability. However, when subjected to external forces such as extrusion, impact or surgery, it will lead to bone fracture, nonunion and other serious consequences, and the steady state of the whole-body bone system will be broken. In order to restore the normal anatomical structure and function, the body promotes osteogenic metabolism and repairs bone trauma by inducing osteogenesis and inhibiting apoptosis. Hippo pathway is one of the effective ways of intracellular and extracellular signal transmission, regulating the processes of cell proliferation and differentiation, and affecting the osteogenic metabolism. The purpose of this review is to point out the direction of exploring the related potential mechanism. |
| Key words: Hippo signaling pathway Yes-associated protein mesenchymal stem cells osteoblasts |
