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| 环状RNA与神经、肌肉功能及相关疾病的研究进展 |
| 高轶昳1,2,刘菲1*,黄卫2,于阅尽2,周义德1,陈世彩1,郑宏良1,蒋昕怡3 |
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(1. 海军军医大学(第二军医大学)长海医院耳鼻咽喉科, 上海 200433;
2. 上海中医药大学附属第七人民医院耳鼻咽喉科, 上海 200137;
3. 上海市宝山区仁和医院口腔科, 上海 200431
*通信作者) |
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| 摘要: |
| 晚期声带麻痹喉肌功能损伤是咽喉外科亟待解决的难题。环状RNA（circRNA）是通过非经典剪接方式形成的一种内源性环形非编码RNA，它可能通过miRNA海绵、可变剪接调节因子等方式在多种疾病的发生、发展中起重要作用，是潜在的疾病早期诊断生物标志物或干预治疗的新靶点。随着研究的不断深入，circRNA与神经、肌肉功能及相关疾病的关系也受到学者们的广泛关注。本文围绕circRNA的分子特征、形成机制、作用模式及其与神经、肌肉功能、相关疾病的研究进展进行综述，以期为晚期声带麻痹的治疗提供新的思路。 |
| 关键词: 环状RNA 神经系统疾病 神经损伤 肌肉相关疾病 |
| DOI：10.16781/j.0258-879x.2021.03.0301 |
| 投稿时间：2020-08-21修订日期：2020-12-02 |
| 基金项目:国家自然科学基金（81700897，81970868）. |
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| Circular RNA and nerve, muscle functions and related diseases: research progress |
| GAO Yi-yi1,2,LIU Fei1*,HUANG Wei2,YU Yue-jin2,ZHOU Yi-de1,CHEN Shi-cai1,ZHENG Hong-liang1,JIANG Xin-yi3 |
(1. Department of Otolaryngology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Otolaryngology, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China;
3. Department of Stomatology, Renhe Hospital of Baoshan District, Shanghai 200431, China
*Corresponding author) |
| Abstract: |
| Laryngeal muscle function impairment caused by advanced vocal fold paralysis is an urgent problem to be solved in throat surgery. Circular RNA (circRNA) is a kind of endogenous loop non-coding RNA formed by non-classical splicing. It may play an important role in the development and progression of various diseases through microRNA (miRNA) sponge, alternative splicing regulators and so on. It is a potential biomarker for early diagnosis of diseases or a new target for intervention therapy. With the deepening of research, the relationship between circRNA and nerve, muscle functions and related diseases has also been widely concerned by scholars. This review focuses on circRNA's molecular characteristics, formation mechanism, mode of action, and its research progress in nerve, muscle functions and related diseases, so as to provide new ways for the treatment of advanced vocal fold paralysis. |
| Key words: circular RNA nervous system diseases nerve injuries muscle-related diseases |
