| 摘要: |
| IL-18属于IL-1家族，是一种多效性免疫调节因子。IL-18通过诱导γ干扰素发挥强烈的促炎作用，并与多种生殖相关妇科疾病存在关联。本文综述了IL-18的生理作用及其与妇科生殖疾病的相关性，从子宫内膜容受性、卵泡发育、生殖免疫等方面探讨IL-18对女性生殖生理的影响。 |
| 关键词: 白细胞介素18 子宫内膜异位症 多囊卵巢综合征 反复自然流产 子宫内膜容受性 卵泡发育 生殖免疫 |
| DOI：10.16781/j.CN31-2187/R.20210002 |
| 投稿时间：2021-01-03修订日期：2021-08-26 |
| 基金项目:国家自然科学基金（81774352，81573755，81703874，81603646，81503604），上海市妇幼健康中医专项建设项目，上海市科学技术委员会中医引导项目（19401930200）. |
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| Physiological role of interleukin-18 and its correlation with gynecological reproductive diseases: research progress |
| DING Jie,MEI Shan-shan,CHENG Wen,YU Chao-qin* |
(Department of Traditional Chinese Medicine (Gynecology), The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon γ and is associated with diverse reproductive related gynecological diseases. This article reviews the physiological role of IL-18 and its correlation with gynecological reproductive diseases, and discusses the impacts of IL-18 on female reproductive physiology from the perspective of endometrial receptivity, folliclar development, and reproductive immunity. |
| Key words: interleukin-18 endometriosis polycystic ovarian syndrome recurrent spontaneous abortion endometrial receptivity follicular development reproductive immunity |
