| 摘要: |
| 创伤、肿瘤、骨折并发症等造成的大段骨缺损是骨科领域的常见问题，传统治疗大段骨缺损采用的骨移植法由于材料来源有限、治疗周期长、并发症多等问题限制了自体或异体骨移植的应用和临床治疗效果。近年来，脂肪干细胞（ADSC）在骨组织工程中的应用为治疗大段骨缺损提供了新的思路和视角，很大程度上克服了传统骨移植的缺点与不足。多种因素在ADSC的成骨分化中发挥了重要作用，本文对骨组织工程中ADSC成骨分化的影响因素及其研究进展进行综述。 |
| 关键词: 骨组织工程 支架 脂肪干细胞 成骨 机械力 外泌体 |
| DOI：10.16781/j.CN31-2187/R.20211036 |
| 投稿时间：2021-10-15修订日期：2022-01-06 |
| 基金项目:国家自然科学基金（81772343）. |
|
| Influencing factors of osteogenic differentiation of adipose derived stem cells in bone tissue engineering: research progress |
| ZHANG Hao-chen1,YANG Xiang-qun2,NIU Yun-fei1* |
(1. Department of Orthopaedics Trauma, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Anatomy, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Large bone defects caused by trauma, tumor, fracture complications, etc. are common problems in the field of orthopaedics. Due to limited material source, long treatment period and various complications, the application and clinical effect of autologous or allogeneic bone transplantation are limited by the traditional bone grafting method for the treatment of large bone defects. In recent years, the application of adipose derived stem cells (ADSCs) in bone tissue engineering provides a new idea and perspective for the treatment of large bone defects, and to a large extent overcomes the shortcomings and deficiencies of traditional bone transplantation. Many factors play important roles in the osteogenic differentiation of ADSCs. The influencing factors and research progress of osteogenic differentiation of ADSCs in bone tissue engineering are reviewed in this paper. |
| Key words: bone tissue engineering scaffold adipose derived stem cell osteogenesis mechanical force exosome |
