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| 外泌体在铁死亡相关疾病中的作用及靶向治疗策略研究进展 |
| 张立1,2,杨珊珊3,王培1,朱宇4,刘旭雯1,2,肖健1,2* |
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(1. 海军军医大学(第二军医大学)第二附属医院胸心外科, 上海 200003;
2. 广西大学医学院, 南宁 530004;
3. 海军军医大学(第二军医大学)第一附属医院特需诊疗科二病区, 上海 200433;
4. 上海理工大学健康科学与工程学院, 上海 200093
*通信作者) |
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| 摘要: |
| 铁死亡是一种铁依赖性非细胞凋亡的程序性细胞死亡方式。迄今为止，铁死亡已被证明参与了许多疾病的病理生理机制，如神经退行性疾病、缺血/再灌注损伤和肿瘤等。外泌体作为细胞间的信息传递途径，已被证明在铁死亡进程中具有重要调控意义。同时，外泌体作为一种免疫原性低、生物相容性好、效率高的药物传递载体，在疾病治疗中的应用愈发广泛。本文总结了近年外泌体在铁死亡相关疾病发生机制中的调控作用及以铁死亡为靶点的新型外泌体治疗策略的研究进展。 |
| 关键词: 铁死亡 外泌体 肿瘤微环境 靶向治疗 |
| DOI：10.16781/j.CN31-2187/R.20220362 |
| 投稿时间：2022-04-30修订日期：2022-09-27 |
| 基金项目:国家自然科学基金（82070255），海军军医大学（第二军医大学） “远航” 军事医学人才项目（2019 ?YH-12），海军军医大学（第二军医大学）深蓝人才工程（SL03）． |
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| Role of exosomes in ferroptosis-related diseases and targeted therapeutic strategies: research progress |
| ZHANG Li1,2,YANG Shanshan3,WANG Pei1,ZHU Yu4,LIU Xuwen1,2,XIAO Jian1,2* |
(1. Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China;
2. Medical College of Guangxi University, Nanning 530004, Guangxi, China;
3. The Second Ward, Department of VIP Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
4. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
*Corresponding author) |
| Abstract: |
| Ferroptosis is an iron-dependent, non-apoptotic programmed cell death pattern. So far ferroptosis has been proved to be involved in the pathophysiological mechanisms of many diseases, such as neurodegenerative diseases, ischemia/ reperfusion injury, and tumors. Exosomes, as an intercellular messaging pathway, have been reported to play an important role in regulating ferroptosis process. Meanwhile, exosomes are increasingly used in diseases as a drug delivery vehicle due to low immunogenicity, good biocompatibility, and high efficiency. This article summarizes the regulatory role of exosomes in ferroptosis-related diseases and novel exosome therapeutic strategies targeting ferroptosis. |
| Key words: ferroptosis exosomes tumor microenvironment targeted therapy |
