| 摘要: |
| 目的：研究抗CD3-抗胶质瘤双特异性抗体 (双抗)对裸鼠体内人脑胶质瘤生长的影响。方法：动物分为6组，实验组系双抗治疗组，其余为不同的对照组，采用人脑胶质瘤裸鼠模型NHG-1，分别观察各组中肿瘤的出现、生长及宿主的生存情况。结果：在实验组中，肿瘤出现的平均潜伏期、肿瘤细胞生长周期时间以及动物的生存期均比各对照组延长(P<0.05或P<0.01)；肿瘤增殖曲线显示，经几周缓慢生长后，各对照组先后进入快速生长期，而经双抗治疗的实验组，肿瘤始终处于缓慢生长状态。结论：抗CD3-抗胶质瘤双特异性抗体可以延缓人脑胶质瘤在动物体内的生长速度，具有临床应用潜力。 |
| 关键词: 抗体，双特异性、神经胶质瘤 |
| DOI： |
|
| 基金项目: |
|
| Effect of anti-CD3-anti-glioma bispecific antibody on human glioma growth in nude mice |
| 周晓平,黄强,沈茜,王文仲,朱诚,卢亦成,楼美清 |
| () |
| Abstract: |
| Objective: To study the effect of anti-CD3-anti-glioma bispecific antibody (BsAb) on human glioma growth in nude mice. Methods: There were 6 groups in these experiments, basic group was treated with BsAb, others were different control groups. Nude mice-human glioma model NHG-1 was used to observe the occurence, growth of the tumor and survival periods. Results: In the basic group, the average incubation period, average tumor cells cycle, and average survival periods were postponed compared with all control groups (P<0.05 or P<0.01). According to tumor growth trend, different control groups went into rapid growth at different time after several week′s slow growth. However, the basic group treated with BsAb lived in a slow growth rate in the whole survival. Conclusion: BsAb can decrease the growth rate of tumor in nude mice, and it may has potential usage in clinic. |
| Key words: antibody, bispecific glioma |
